*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
The peptide used to generate this antibody is available for purchase (GTX88466-PEP).
Mouse, Rat, Bovine(>80% identity)
Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.50 mg/ml (Please refer to the vial label for the specific concentration.)
Peptide with sequence C-HDKETYKLQRRETIK, from the internal region of the protein sequence according to NP_068839.1.
Purified by ammonium sulphate precipitation followed by antigen affinity chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Integral Membrane Protein 2B,Abri,Bri,Bri2,Bricd2B,E25B,E3-16,Fbd,Rdgca,Imbri2,Itm2B
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
GTX88466 IHC-P Image
IHC-P analysis of human small intestine using GTX88466 ITM2B antibody, Internal.
Antigen retrieval : citrate buffer pH 6
Dilution : 2.5µg/ml
GTX88466 WB Image
WB analysis of human hippocampus lysate using GTX88466 ITM2B antibody, Internal.
Dilution : 1µg/ml
Loading : 35µg protein in RIPA buffer