GeneTex
United States (US)

ITM2B antibody, Internal

GTX88466_946_IHC-P_18121411_356.jpg
GTX88466_2287_WB_18121411_967.jpg

Cat No. GTX88466

Host Goat
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1-3μg/ml
IHC-P 2.5μg/ml
Not tested in other applications.

Calculated MW

30 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX88466-PEP).

Predict Reactivity

Mouse, Rat, Bovine(>80% identity)
PROPERTIES

Form

Liquid

Buffer

Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide with sequence C-HDKETYKLQRRETIK, from the internal region of the protein sequence according to NP_068839.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Integral Membrane Protein 2B,Abri,Bri,Bri2,Bricd2B,E25B,E3-16,Fbd,Rdgca,Imbri2,Itm2B

Background

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]

Database

DATA IMAGES
GTX88466_946_IHC-P_18121411_356.jpg

GTX88466 IHC-P Image

IHC-P analysis of human small intestine using GTX88466 ITM2B antibody, Internal.
Antigen retrieval : citrate buffer pH 6
Dilution : 2.5µg/ml

GTX88466_2287_WB_18121411_967.jpg

GTX88466 WB Image

WB analysis of human hippocampus lysate using GTX88466 ITM2B antibody, Internal.
Dilution : 1µg/ml
Loading : 35µg protein in RIPA buffer

Package List Price ($)
$ 329