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Iba1 antibody

Orthogonal
Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042
Anti-Iba1 antibody used in Western Blot (WB). GTX100042
Anti-Iba1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX100042
Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042
Anti-Iba1 antibody used in Western Blot (WB). GTX100042
Anti-Iba1 antibody used in Western Blot (WB). GTX100042
Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042
Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042
Anti-Iba1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX100042
Anti-Iba1 antibody used in Western Blot (WB). GTX100042
Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042
Anti-Iba1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX100042
Anti-Iba1 antibody used in Flow cytometry (FACS). GTX100042
Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042
Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042
Anti-Iba1 antibody used in Western Blot (WB). GTX100042

Cat. No. GTX100042

Reference 75
14

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IHC-Fr, FACS, IHC, IHC (Free Floating)

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399),
25 μl ($169)
See all Iba1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:10000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
IHC-Fr 1:100-1:1000
FACS 1:50-1:200
IHC Assay dependent
IHC (Free Floating) Assay dependent
Not tested in other applications.

Calculated MW

17 kDa. ( Note )

Positive Control

mouse liver , rat liver

Predict Reactivity

Bovine, Pig, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

1XPBS (pH7), 1% BSA, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.06 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Iba1. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1240434

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

allograft inflammatory factor 1 , AIF-1 , IBA1 , IRT-1 , IRT1

Background

This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042

GTX100042 IHC-P Image

Iba1 antibody detects Iba1 protein on rat hind brain by immunohistochemical analysis.
Sample: Paraffin-embedded rat hind brain.
Iba1 antibody (GTX100042) dilution: 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-Iba1 antibody used in Western Blot (WB). GTX100042

GTX100042 WB Image

Rat tissue extract (50 μg) was separated by 15% SDS-PAGE, and the membrane was blotted with Iba1 antibody (GTX100042) diluted at 1:1000.

Anti-Iba1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX100042

GTX100042 IHC-Fr Image

Iba1 antibody detects Iba1 protein expression at microglias by immunohistochemical analysis.
Sample: Frozen sectioned E13.5 Rat brain.
Green: Iba1 protein stained by Iba1 antibody (GTX100042) diluted at 1:250.
Red: beta Tubulin 3/ TUJ1, a mature neuron marker, stained by beta Tubulin 3/ TUJ1 antibody [GT11710] (GTX631836) diluted at 1:500.
Blue: Fluoroshield with DAPI (GTX30920).
Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042

GTX100042 IHC-P Image

Immunohistochemical analysis of paraffin-embedded human hepatoma, using Iba1(GTX100042) antibody at 1:500 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min
Iba1 antibody detects Iba1 in the cytosol of Kupffer cell in human hepatoma by immunohistochemical analysis.

Anti-Iba1 antibody used in Western Blot (WB). GTX100042

GTX100042 WB Image

Various tissue extracts (50 μg) were separated by 15% SDS-PAGE, and the membrane was blotted with Iba1 antibody (GTX100042) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Iba1 antibody used in Western Blot (WB). GTX100042

GTX100042 WB Image

Orthogonal

Various whole cell extracts (30 μg) were separated by 15% SDS-PAGE, and the membrane was blotted with Iba1 antibody (GTX100042) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody. Correspo

Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042

GTX100042 IHC-P Image

Iba1 antibody detects Iba1 protein at cell membrane and cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded mouse cerebellum.
Iba1 stained by Iba1 antibody (GTX100042) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042

GTX100042 IHC-P Image

Iba1 antibody detects Iba1 protein at cell membrane and cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded rat cerebellum.
Iba1 stained by Iba1 antibody (GTX100042) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Iba1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX100042

GTX100042 ICC/IF Image

Iba1 antibody detects Iba1 protein at cytoplasm by immunofluorescent analysis.
Sample: THP-1 cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: Iba1 stained by Iba1 antibody (GTX100042) diluted at 1:500.
Blue: Fluoroshield with DAPI (GTX30920).

Anti-Iba1 antibody used in Western Blot (WB). GTX100042

GTX100042 WB Image

Mouse tissue extract (50 μg) was separated by 15% SDS-PAGE, and the membrane was blotted with Iba1 antibody (GTX100042) diluted at 1:1000.

Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042

GTX100042 IHC-P Image

Iba1 antibody detects Iba1 protein on mouse fore brain by immunohistochemical analysis.
Sample: Paraffin-embedded mouse fore brain.
Iba1 antibody (GTX100042) dilution: 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-Iba1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX100042

GTX100042 IHC-Fr Image

Iba1 antibody detects Iba1 protein at cell membrane and cytoplasm by immunohistochemical analysis.
Sample: Frozen-sectioned mouse brain.
Green: Iba1 stained by Iba1 antibody (GTX100042) diluted at 1:500.
Blue: Fluoroshield with DAPI (GTX30920).
Antigen Retrieval: ice-cold MeOH for 5 min

Anti-Iba1 antibody used in Flow cytometry (FACS). GTX100042

GTX100042 FACS Image

Iba1 antibody (GTX100042) detects AIF1 protein by flow cytometry analysis.
Sample: THP-1 cell.
Black: Unlabelled sample was used as a control.
Red: Iba1 antibody (GTX100042) dilution: 1:50.
Acquisition of 20,000 events were collected for FACS analysis.

Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042

GTX100042 IHC-P Image

Iba1 antibody detects Iba1 protein at cell membrane and cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded rat brain.
Iba1 stained by Iba1 antibody (GTX100042) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042

GTX100042 IHC-P Image

Iba1 antibody detects Iba1 protein at cell membrane and cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded mouse brain.
Iba1 stained by Iba1 antibody (GTX100042) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Iba1 antibody used in Western Blot (WB). GTX100042

GTX100042 WB Image

Various whole cell extracts (30 μg) were separated by 15% SDS-PAGE, and the membrane was blotted with Iba1 antibody (GTX100042) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

REFERENCE

Application Reference

Md Sadikul Islam et al. BMC Complement Med Ther 2022; 22 (1) : 172 Fermented Mentha arvensis administration provides neuroprotection against transient global cerebral ischemia in gerbils and SH-SY5Y cells via downregulation of the MAPK signaling pathway.
Shaowei Wang et al. Mol Neurodegener 2022; 17 (1) : 42 Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4.
Application : WB
Reactivity : Human, Mouse
Yingli Jing et al. Microbiol Spectr 2022; 10 (3) : e0017722 Fecal Microbiota Transplantation Exerts Neuroprotective Effects in a Mouse Spinal Cord Injury Model by Modulating the Microenvironment at the Lesion Site.
Application : WB, IHC-Fr
Reactivity : Mouse
Ryoji Amamoto et al. Elife 2022; 11 Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration.
Application : IHC-Fr
Reactivity : Human
Adriana Sofranko et al. Part Fibre Toxicol 2022; 19 (1) : 23 Effects of subchronic dietary exposure to the engineered nanomaterials SiO2 and CeO2 in C57BL/6J and 5xFAD Alzheimer model mice.
Application : WB, IHC-P
Reactivity : Mouse
Show More +
Submit a Reference

REVIEW

Iba1 antibody Cat. No. GTX100042

Rating
( Average 4.9 based on 14 users reviews)
Application
Western Blot(WB)
( Average 5 based on 2 users reviews)
Immunocytochemistry/ Immunofluorescence(ICC/IF)
( Average 5 based on 1 users reviews)
IHC (Paraffin sections)(IHC-P)
( Average 5 based on 2 users reviews)
IHC (Frozen sections)(IHC-Fr)
( Average 5 based on 5 users reviews)
Immunohistochemistry(IHC)
( Average 4.7 based on 3 users reviews)
IHC (Free Floating)(IHC (Free Floating))
( Average 5 based on 1 users reviews)
Anti-Iba1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX100042
Date : Anonymous submitted on 11-Apr-2022
Score :
Application Tested : IHC-Fr
Sample Species : Rat
Sample : Rat brain tissue section
Blocking : 2% goat serum, 20-25°C, 1Hr
Fixation : formalin (4C, 3 days) and then replace it to Sucrose
Permeabilization /Antigen retrieval : 0.1%Triton in Tris Buffered Saline
Primary Antibody : 1:250, 4°C, 12Hr
Lane Description :
Green : GTX100042
Blue : DAPI
Anti-Iba1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX100042
Date : Anonymous submitted on 15-Feb-2022
Score :
Application Tested : IHC-Fr
Sample Species : Rat
Sample : Rat brain tissue section
Blocking : 10% gout serum and 0.01% Triton X-100 in PBS pH7.4, RT, 1Hr
Fixation : 4% PFA
Primary Antibody : 1:200 in blocking buffer, 4°C, 12Hr
Lane Description :
Red : GTX100042
Blue : DAPI
Anti-Iba1 antibody used in Western Blot (WB). GTX100042
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal EMBO Mol Med in 2019.PMID: 31122931
Anti-Iba1 antibody used in Western Blot (WB). GTX100042
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Sci Rep in 2016.PMID: 26750705
Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : IHC-P
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Sci Rep in 2019.PMID: 31578352
Anti-Iba1 antibody used in IHC (Free Floating) (IHC (Free Floating)). GTX100042
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : IHC (Free Floating)
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Front Immunol in 2018.PMID: 29662492
Anti-Iba1 antibody used in Immunohistochemistry (IHC). GTX100042
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : IHC
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Sci Rep in 2016.PMID: 27824125
Anti-Iba1 antibody used in Immunohistochemistry (IHC). GTX100042
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : IHC
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Sci Rep in 2016.PMID: 27824125
Anti-Iba1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX100042
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : ICC/IF
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Dis Model Mech in 2016. PMID: 27491075
Anti-Iba1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX100042
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : IHC-Fr
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal J Neuroinflammation in 2018. PMID: 29753328
Anti-Iba1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX100042
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : IHC-Fr
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal J Neuroinflammation in 2018. PMID: 29753328
Anti-Iba1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100042
Date : Anonymous submitted on 15-Dec-2020
Score :
Application Tested : IHC-P
Sample Species : Ms
Sample : brain tissue
Blocking : 1% BSA, 25°C, 0.5Hr
Fixation : 4% Paraformaldehyde
Permeabilization /Antigen retrieval : 0.4% TritonX-100, 25°C, 0.5Hr
Primary Antibody : 1:500, 4°C, 24Hr
Figure Note : Green: Iba1
Anti-Iba1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX100042
Date : Anonymous submitted on 05-Jun-2018
Score :
Application Tested : IHC-Fr
Sample Species : Rat
Sample : Brain
Fixation : 4% PFA, 4°C, 48Hr
Primary Antibody : 1:100, 4°C, 16Hr
Anti-Iba1 antibody used in Immunohistochemistry (IHC). GTX100042
Date : Anonymous submitted on 18-Mar-2013
Score :
Application Tested : IHC
Sample Species : Ms
Sample : Mouse brain
Blocking : NGS,BSA,Trition X-100, 25°C, 2Hr
Fixation : 4% PFA
Permeabilization /Antigen retrieval : 0.1M citrate buffer(pH6.0), 95°C, 10minHr
Primary Antibody : 1:1000, 25°C, 18Hr
Show More +
Submit a Review
Application Reference
Md Sadikul Islam et al. BMC Complement Med Ther 2022; 22 (1):172 Fermented Mentha arvensis administration provides neuroprotection against transient global cerebral ischemia in gerbils and SH-SY5Y cells via downregulation of the MAPK signaling pathway.
Shaowei Wang et al. Mol Neurodegener 2022; 17 (1):42 Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4.
Application : WB
Reactivity : Human, Mouse
Yingli Jing et al. Microbiol Spectr 2022; 10 (3):e0017722 Fecal Microbiota Transplantation Exerts Neuroprotective Effects in a Mouse Spinal Cord Injury Model by Modulating the Microenvironment at the Lesion Site.
Application : WB, IHC-Fr
Reactivity : Mouse
Ryoji Amamoto et al. Elife 2022; 11 Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration.
Application : IHC-Fr
Reactivity : Human
Adriana Sofranko et al. Part Fibre Toxicol 2022; 19 (1):23 Effects of subchronic dietary exposure to the engineered nanomaterials SiO2 and CeO2 in C57BL/6J and 5xFAD Alzheimer model mice.
Application : WB, IHC-P
Reactivity : Mouse
Huang WY et al. J Neuroinflammation 2022; 19 (1):29 TNFα-mediated necroptosis in brain endothelial cells as a potential mechanism of increased seizure susceptibility in mice following systemic inflammation.
Application : IHC-Fr
Reactivity : Mouse
Yu-En Lin et al. Elife 2021; 10 Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson's disease.
Application : IHC
Reactivity : Mouse
Mireia Recasens et al. J Neuroinflammation 2021; 18 (1):31 Chronic exposure to IL-6 induces a desensitized phenotype of the microglia.
Application : WB
Reactivity : Mouse
Shaowei Wang et al. Mol Neurodegener 2021; 16 (1):26 Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4.
Application : WB
Reactivity : Mouse
Alessandro Venturino et al. Cell Rep 2021; 36 (1):109313 Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain.
Application : IHC-Fr
Reactivity : Mouse
Sheng-Han Lee et al. PLoS One 2021; 16 (8):e0254587 Three month inhalation exposure to low-level PM2.5 induced brain toxicity in an Alzheimer's disease mouse model.
Application : WB
Reactivity : Mouse
Margaret E Maes et al. Mol Ther Methods Clin Dev 2021; 23:210-224 Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment.
Application : IHC
Reactivity : Mouse
Venturino A et al. STAR Protoc 2021; 2 (4):101012 Minimally invasive protocols and quantification for microglia-mediated perineuronal net disassembly in mouse brain.
Reactivity : Mouse
Su X et al. Ecotoxicol Environ Saf 2021; 225:112806 Chronic developmental exposure to low-dose ([C8mim][PF6]) induces neurotoxicity and behavioural abnormalities in rats.
Application : WB, IHC-Fr
Reactivity : Rat
Farrher E et al. Neuroimage 2021; 244:118605 Spatiotemporal characterisation of ischaemic lesions in transient stroke animal models using diffusion free water elimination and mapping MRI with echo time dependence.
Application : IHC-P
Reactivity : Rat
Keerie A et al. Sci Rep 2021; 11 (1):17027 The GLP-1 receptor agonist, liraglutide, fails to slow disease progression in SOD1G93A and TDP-43Q331K transgenic mouse models of ALS.
Application : IHC-P
Reactivity : Mouse
Couto E Silva A et al. J Neurochem 2021; (Epub) Protein arginine methyltransferase 8 modulates mitochondrial bioenergetics and neuroinflammation after hypoxic stress.
Wang M et al. J Neuroinflammation 2021; 18 (1):146 Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.
Application : WB
Reactivity : Mouse
Hara T et al. Cancer Cell 2021; 39 (6):779-792.e11 Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.
Application : IHC-Fr
Reactivity : Mouse
Chang CW et al. EJNMMI Res 2021; 11 (1):26 GMP-compliant fully automated radiosynthesis of [18F]FEPPA for PET/MRI imaging of regional brain TSPO expression.
Application : WB, IHC-Fr
Reactivity : Mouse
Ma P et al. J Mol Cell Biol 2021; (Epub) Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse.
Application : IHC-P
Reactivity : Mouse
Wu CY et al. Prostaglandins Leukot Essent Fatty Acids 2021; 165:102227 Palmitic acid methyl ester inhibits cardiac arrest-induced neuroinflammation and mitochondrial dysfunction.
Reactivity : Mouse
Yang L et al. Phytomedicine 2021; 80:153385 Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK/AKT/NFκB signaling pathway.
Application : WB
Reactivity : Mouse
Gemma Manich et al. Front Cell Neurosci 2020; 14:567404 Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models.
Application : IHC-Fr
Reactivity : Mouse
Liu XG et al. J Nanobiotechnology 2020; 18 (1):160 Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer's Disease.
Toral-Rios D et al. Int J Mol Sci 2020; 21 (20) Activation of STAT3 Regulates Reactive Astrogliosis and Neuronal Death Induced by AβO Neurotoxicity.
Kaehler K et al. Invest Ophthalmol Vis Sci 2020; 61 (6):12 Assessment of the Retina of Plp-α-Syn Mice as a Model for Studying Synuclein-Dependent Diseases.
Zuliani I et al. Neurotherapeutics 2020; (Epub) The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome.
Application : WB
Reactivity : Mouse
Cao K et al. Aging (Albany NY) 2020; 12 (2):1792-1807 The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of α7 nicotinic acetylcholine receptors.
Li H et al. Int J Biol Sci 2020; 16 (7):1107-1120 C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment.
Ding B et al. J Neuroinflammation 2020; 17 (1):302 Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro.
Application : IHC-Fr
Reactivity : Mouse
Lee RH et al. Am J Physiol Heart Circ Physiol 2020; 319 (5):H1044-H1050 Upregulation of serum and glucocorticoid-regulated kinase 1 exacerbates brain injury and neurological deficits after cardiac arrest.
Reactivity : Rat
Werner G et al. EMBO Rep 2020; 21 (10):e50241 Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
Application : WB, IHC-Fr
Reactivity : Mouse
Di Domenico M et al. Neurotoxicology 2020; 79:127-141 Concentrated ambient fine particulate matter (PM2.5) exposure induce brain damage in pre and postnatal exposed mice.
Application : IHC-P
Reactivity : Mouse
Wahle T et al. Neurochem Int 2020; 138:104755 Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer's and vascular disease.
Application : IHC-P
Reactivity : Mouse
Patrick L?ningschr?r et al. Cell Rep 2020; 30 (10):3506-3519.e6 The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.
Application : IHC-Fr
Reactivity : Mouse
Sozmen M et al. J Comp Pathol 2020; 176:71-75 Primary Unilateral Small Cell Neuroendocrine Carcinoma of the Kidney in a Dog.
Application : IHC-P
Zhao Y et al. Neurochem Res 2020; 45 (5):1180-1190 MSCs-Derived Exosomes Attenuate Acute Brain Injury and Inhibit Microglial Inflammation by Reversing CysLT2R-ERK1/2 Mediated Microglia M1 Polarization.
Application : ICC/IF
Reactivity : Rat
Petrushina I et al. Neurobiol Dis 2020; 139:104823 Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials.
Application : IHC-P
Reactivity : Mouse
Yu XL et al. Br J Pharmacol 2020; Vaccines Targeting the Primary Amino Acid Sequence and Conformational Epitope of Amyloid-β Had Distinct Effects on Neuropathology and Cognitive Deficits in EAE/AD Mice.
Application : IHC-P
Reactivity : Mouse
Patrick Lüningschrör et al. Cell Rep. 2020; 30 (10):3506-3519.e6 The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.
Application : IHC
Reactivity : Mouse
Cao K et al. Alzheimers Res Ther 2019; 11 (1):35 Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation.
Hong Zeng et al. Journal of Neuroinflammation 2019; (Epub) Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury.
Reactivity : Rat
Hong Li et al. bioRxiv 2019; (Epub) C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment.
Application : IHC-Fr
Reactivity : Mouse
Olechnowicz SWZ et al. Sci Rep 2019; 9 (1):14189 Multiple myeloma increases nerve growth factor and other pain-related markers through interactions with the bone microenvironment.
Application : IHC-P
Reactivity : Mouse
Pejman S et al. Brain Res Bull 2019; Ac-SDKP ameliorates the progression of experimental autoimmune encephalomyelitis via inhibition of ER stress and oxidative stress in the hippocampus of C57BL/6 mice.
Application : IHC-P
Reactivity : Mouse
Bai KJ et al. Chem Biol Interact 2019; 311:108762 Microglial activation and inflammation caused by traffic-related particulate matter.
Application : IHC-P
Reactivity : Rat
Zhang T et al. FASEB J 2019;:fj201802614RRR Erianin alleviates diabetic retinopathy by reducing retinal inflammation initiated by microglia cells via inhibiting hyperglycemia-mediated ERK1/2-NF-庥B signaling pathway.
Application : WB, IHC
Reactivity : Rat
Liao KH et al. Brain Res 2019;:146320 Carbogen inhalation opens the blood-brain barrier in rats without causing long-term metabolic or neurological deficit.
Application : WB
Reactivity : Rat
Marques ARA et al. Autophagy 2019;:1-15 Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
Application : IHC-P
Reactivity : Mouse
G?tzl JK et al. EMBO Mol Med 2019; 11 (6) Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
Application : WB
Reactivity : Mouse
Kamarehei M et al. Brain Res Bull 2019; 147:174-182 Increased expression of endoplasmic reticulum stress-related caspase-12 and CHOP in the hippocampus of EAE mice.
Application : IHC-P
Reactivity : Mouse
Bartsch K et al. Front Immunol 2018; 9:587 RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation.
Wahl D et al. Cell Rep 2018; 25 (8):2234-2243.e6 Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.
Application : IHC-Fr
Reactivity : Mouse
Huang YR et al. Neurobiol Dis 2018; 124:202-217 Naturally occurring autoantibodies against α-synuclein rescues memory and motor deficits and attenuates α-synuclein pathology in mouse model of Parkinson's disease.
Application : IHC-P
Reactivity : Mouse
Josephine Juettner et al. bioRxiv 2018; (Epub) Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates, and humans.
Application : IHC-Fr
Reactivity : Human
Jhan MK et al. J Leukoc Biol 2018; (Epub) Anti-TNF-α restricts dengue virus-induced neuropathy.
Application : IHC-Fr
Reactivity : Mouse
Ji M et al. Alzheimers Res Ther 2018; 10 (1):55 Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer's disease and frontotemporal dementia.
Application : IHC-P
Reactivity : Mouse
Liu SY et al. Brain Res 2018; (Epub) Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington's disease by decreasing mutant huntingtin protein level and normalizing NF-κB signaling pathway.
Huang WY et al. J Neuroinflammation 2018; 15 (1):140 NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation.
Application : WB
Reactivity : Mouse
Hashiguchi T et al. Drug Metab Dispos 2018; (Epub) Sulfotransferase 4A1 (SULT4A1) increases its expression in mouse neurons as they mature.
Application : ICC/IF
Reactivity : Mouse
Huang YN et al. Sci Rep 2018; 8 (1):2368 Neuroprotective effects of pifithrin-α against traumatic brain injury in the striatum through suppression of neuroinflammation, oxidative stress, autophagy, and apoptosis.
Application : IHC
Reactivity : Rat
Souza LC et al. Mol Cell Neurosci 2018; 88:93-106 Aging exacerbates cognitive and anxiety alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice.
Application : IHC-P
Reactivity : Mouse
Lin W et al. Cell Transplant 2017; 26 (11):1798-1810 Human Umbilical Cord Mesenchymal Stem Cells Preserve Adult Newborn Neurons and Reduce Neurological Injury after Cerebral Ischemia by Reducing the Number of Hypertrophic Microglia/Macrophages.
Application : IHC-P
Reactivity : Rat
Ingold I et al. Cell 2017; (Epub) Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.
Application : IHC-Fr
Reactivity : Mouse
Lin HJ et al. Cell Physiol Biochem 2017; 44 (5):1726-1740 Gamma-Secretase Inhibitors Attenuate Neurotrauma and Neurogenic Acute Lung Injury in Rats by Rescuing the Accumulation of Hypertrophic Microglia.
Application : IHC-P
Reactivity : Rat
Huang N et al. Oncotarget 2017; 8 (46):81001-81013 PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering Aβ generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer's disease mice.
Application : WB, IHC-P
Reactivity : Mouse
Zera K et al. PLoS One 2017; 12 (10):e0186707 Thiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes.
Application : WB
Reactivity : Mouse
Stroobants S et al. Neurobiol Dis 2017; Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice.
Application : IHC-Fr
Reactivity : Mouse
Wang SW et al. Alzheimers Res Ther 2017; 9 (1):41 A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease.
Application : IHC-Fr
Reactivity : Mouse
Wolf H et al. Dis Model Mech 2016; 9 (9):1015-28 A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease.
Application : ICC/IF
Reactivity : Mouse
Zha J et al. Sci Rep 2016; 6:36631 A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses.
Application : IHC-P
Reactivity : Mouse
Liu HS et al. Sci Rep 2016; 6:19137 Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway.
Kowalewski B et al. Hum Mol Genet 2015; 24 (7):1856-68 Ataxia is the major neuropathological finding in arylsulfatase G-deficient mice: similarities and dissimilarities to Sanfilippo disease (mucopolysaccharidosis type III).
Application : IHC
Reactivity : Mouse
Kowalewski B et al. Hum. Mol. Genet. 2014; 24 (7):1856-68 Ataxia is the major neuropathological finding in Arylsulfatase G deficient mice: Similarities and dissimilarities to Sanfilippo disease (Mucopolysaccharidosis type III).
Application : IHC-Fr
Reactivity : Mouse
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