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Ikaros antibody [1A12-F2-D8]

Anti-Ikaros antibody [1A12-F2-D8] used in Western Blot (WB). GTX49214
Anti-Ikaros antibody [1A12-F2-D8] used in Immunoprecipitation (IP). GTX49214

Cat No. GTX49214

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 1A12-F2-D8

Isotype

 IgG1

Application

 WB, IP

Reactivity

 Human
Package
100 μg ($319)
See all Ikaros products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

58 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified recombinant human Ikaros(C-terminus) protein fragments expressed in E.coli.

Purification

Affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Ikaros Family Zinc Finger 1 , Cvid13 , Hs.54452 , Ik1 , Ikaros , Lyf1 , Lyf-1 , Ppp1R92 , Pro0758 , Znfn1A1 , Ikzf1

Cellular Localization

Nucleus

Background

Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs).

Database

Research Area

DATA IMAGES

Anti-Ikaros antibody [1A12-F2-D8] used in Western Blot (WB). GTX49214

GTX49214 WB Image

WB analysis of Ramos and Jurkat lysates using Ikaros antibody at a dilution of 1:1,000.

Anti-Ikaros antibody [1A12-F2-D8] used in Immunoprecipitation (IP). GTX49214

GTX49214 IP Image

IP analysis of HeLa lysate using control IgG and Ikaros antibody. The precipitates were detected by the same Ikaros antibody.

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 319