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Insulin Receptor (phospho Tyr1316) antibody

Anti-Insulin Receptor (phospho Tyr1316) antibody used in IHC (Paraffin sections) (IHC-P). GTX55014
Anti-Insulin Receptor (phospho Tyr1316) antibody used in Western Blot (WB). GTX55014

Cat No. GTX55014

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human, Mouse, Rat
Package
100 μl ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:1000
IHC-P 1:100 - 1:200
Not tested in other applications.

Calculated MW

156 kDa. ( Note )

Product Note

The full-length Insulin Receptor includes the 27 aa signal peptide that is cleaved during maturation. The Tyr1316 of mature Insulin Receptor (P06213-2) is equivalent to Tyr1343 of uncleaved Insulin Receptor (P06213-2) or Tyr1355 of uncleaved Insulin Receptor (P06213-1).

PROPERTIES

Form

Liquid

Buffer

0.42% Potassium phosphate, 0.87% Sodium chloride pH 7.3, 30% glycerol, 0.01% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Insulin Receptor (pY1316). The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

insulin receptor , CD220 , HHF5

Cellular Localization

Cell membrane; Single-pass type I membrane protein

Background

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Database

Research Area

DATA IMAGES

Anti-Insulin Receptor (phospho Tyr1316) antibody used in IHC (Paraffin sections) (IHC-P). GTX55014

GTX55014 IHC-P Image

IHC-P analysis of formalin fixed human lung cancer tissue section using GTX55014 Insulin Receptor (phospho Tyr1316) antibody.
Antigen retrieval : Heat mediated antigen retrieval with sodium citrate buffer (pH 6.0)

Anti-Insulin Receptor (phospho Tyr1316) antibody used in Western Blot (WB). GTX55014

GTX55014 WB Image

WB analysis of insulin-treated HeLa (A), mouse brain (B), rat brain (C) whole cell lysates using GTX55014 Insulin Receptor (phospho Tyr1316) antibody.

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Sodium Azide.pdf