*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
The full-length Insulin Receptor includes the 27 aa signal peptide that is cleaved during maturation. The Tyr960 of mature Insulin Receptor(P06213-2) is equivalent toTyr972 of mature Insulin Receptor (P06213-1).
PBS pH 7.3, 50% glycerol, 1mg/ml BSA, 0.05% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Batch dependent (Please refer to the vial label for the specific concentration.)
Synthetic phosphopeptide derived from the region of the human Insulin Receptor that contains tyrosine 960.
Purified by antigen-affinity chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
insulin receptor , CD220 , HHF5
Cell membrane; Single-pass type I membrane protein
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]