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Insulin antibody [HMV308] HistoMAX™

Recombinant antibody Orthogonal HistoMAX
Anti-Insulin antibody [HMV308] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639932
Anti-Insulin antibody [HMV308] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639932
Anti-Insulin antibody [HMV308] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639932

Cat. No. GTX639932

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 HMV308

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($649),
100 μl ($329)
See all Insulin products
PRODUCT

Summary

Go to Normal Tissue GalleryGo to Cancer Tissue Gallery

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100-1:200

Note :

IHC-P
Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 7.8 Target Retrieval Solution buffer.
Not tested in other applications.

Positive Control

Normal Pancreas

Negative Control

Normal Colon

Predict Reactivity

Rabbit, Bovine, Cat, Dog, Pig, Chimpanzee(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 2% BSA

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

batch dependent

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human insulin. The exact sequence is proprietary.

Purification

Affinity purified by Protein A.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

insulin,IDDM,IDDM1,IDDM2,ILPR,IRDN,MODY10

Cellular Localization

Secreted

Background

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Database

Research Area

DATA IMAGES

Anti-Insulin antibody [HMV308] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639932

GTX639932 IHC-P Image

IHC-P analysis of human insulinoma (pancreatic neuroendocrine tumor) tissue using GTX639932 Insulin antibody [HMV308] HistoMAX™. Pancreatic neuroendocrine tumor (insulinoma) with strong Insulin positivity of most tumor cells.

Anti-Insulin antibody [HMV308] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639932

GTX639932 IHC-P Image

IHC-P analysis of human pancreas tissue using GTX639932 Insulin antibody [HMV308] HistoMAX™. Pancreas with a strong cytoplasmic insulin staining of the majority of islet cells.

Anti-Insulin antibody [HMV308] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639932

GTX639932 IHC-P Image

IHC-P analysis of human colon tissue using GTX639932 Insulin antibody [HMV308] HistoMAX™. Colon sample completely lacking insulin staining.

REFERENCE

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REVIEW

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Package List Price ($)
$ 649
$ 329
Available soon.