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Integrin alpha 2 antibody [AK7]

Cat. No. GTX76461

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 AK7

Isotype

 IgG1

Application

 IHC-Fr, FACS, Neutralizing/Inhibition

Reactivity

 Human, Baboon, Cynomolgus monkey, Rhesus Monkey
Package
200 μg ($459)
See all Integrin alpha 2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-Fr 1/500-1/1,000
FACS 1/50-1/100
Neutralizing/Inhibition Assay dependent

Note :

IHC-Fr
The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. Recommend the use of acetone fixation for frozen sections.

FACS
Use 10μl of the suggested working dilution to label 106 cells in 100μl.

Neutralizing/Inhibition
Mouse anti Human CD49b antibody, clone AK7 inhibits cell attachment to collagen.
Not tested in other applications.

Calculated MW

129 kDa. ( Note )

Product Note

Clone AK7 inhibits cell attachment to collagen.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_377368

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

integrin subunit alpha 2 , BR , CD49B , GPIa , HPA-5 , VLA-2 , VLAA2

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 459