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Integrin alpha 2 antibody [HMa2] (FITC)

Anti-Integrin alpha 2 antibody [HMa2] (FITC) used in Flow cytometry (FACS). GTX01474-06

Cat. No. GTX01474-06

Reference 4

Host

 Armenian Hamster

Clonality

 Monoclonal

Clone Name

 HMa2

Isotype

 IgG

Application

 FACS

Reactivity

 Mouse
Package
100 μg ($199)
See all Integrin alpha 2 products
PRODUCT

Summary

The HMa2 antibody reacts with mouse CD49b, a 150 kDa glycoprotein member of the integrin αfamily. CD49b, also known as integrin αalpha2, associates non-covalently with CD29 (integrin αbeta1) to form the VLA-2 heterodimer. VLA-2 integrin αs function as cellular receptors for collagen and laminin. CD49b is expressed by platelets, intestinal epithelial cells, NK cells, epithelial cells, and a subset of CD4+ T cells. CD49b plays an essential role in mediating the adhesion of cells to the extracellular matrix.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
Not tested in other applications.

Calculated MW

129 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Purification

Purified by affinity chromatography
From tissue culture supernatant

Conjugation

Fluorescein isothiocyanate (FITC)

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Cellular Localization

Membrane

Database

Research Area

DATA IMAGES

Anti-Integrin alpha 2 antibody [HMa2] (FITC) used in Flow cytometry (FACS). GTX01474-06

GTX01474-06 FACS Image

FACS analysis of mouse C57Bl/6 splenocytes using GTX01474-06 Integrin alpha 2 antibody [HMa2] (FITC).
Right panel : co-stained with Integrin alpha 2 antibody [HMa2] (FITC) and Mouse NK1.1 antibody (APC)
Left panel : co-stained with isotype control and Mouse NK1.1 antibody (APC)
antibody amount : 0.25 μg (5 μl)

REFERENCE

Clone Reference

2008; alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner.
2001; Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2).
1995; Identification and functional characterization of mouse CD29 with a mAb.
1994; Identification of collagen and laminin receptor integrins on murine T lymphocytes.
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SDS
Sodium Azide.pdf
Package List Price ($)
$ 199