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Integrin alpha 4 antibody [HP2.1]

Cat. No. GTX44185

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 HP2.1

Isotype

 IgG1

Application

 FACS, IM

Reactivity

 Human
Package
100 μg ($399)
See all Integrin alpha 4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
IM Assay dependent

Note :

FACS
2 μg/5x10⁵ cells/test
Not tested in other applications.

Calculated MW

115 kDa. ( Note )

Product Note

The molecular weight of the recognized antigen is 150 kDa. CD49d antigen is the integrin alpha-4 chain non-covalently associated with the integrin beta-1-chain (CD29 molecule) forming the VLA4 complex. Reacts with monocytes, T cells, B cells, thymocytes and Langerhans cells.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

M Leukemia Line

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

integrin subunit alpha 4 , CD49D , IA4

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399