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Integrin alpha 4 antibody [PS/2] (Azide free)

Cat. No. GTX74789

Reference 3

Host

 Rat

Clonality

 Monoclonal

Clone Name

 PS/2

Isotype

 IgG2b

Application

 IHC-Fr, FACS, IP, Neutralizing/Inhibition

Reactivity

 Human, Mouse
Package
200 μg ($399)
See all Integrin alpha 4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-Fr Assay dependent
FACS 1/50-1/100
IP Assay dependent
Neutralizing/Inhibition Assay dependent

Note :

FACS
Use 10μl of the suggested working dilution to label 106 cells in 100μl.

Neutralizing/Inhibition
Clone PS/2 has been reported to block the binding of CD49d to its ligands (Andrew et al. 1994).
Not tested in other applications.

Calculated MW

116 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_378256

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

integrin alpha 4 , CD49D , Itga4B

Cellular Localization

Membrane; Single-pass type I membrane protein

Database

Research Area

REFERENCE

Clone Reference

Yousef H et al. Nat Med 2019; 25 (6):988-1000 Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.
Abplanalp WT et al. Diabetes 2016; Enhanced Integrin α4β1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes.
D P Andrew et al. J Immunol. 1994; 153 (9):3847-61 Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation
Application : Neutralizing/Inhibition
Reactivity : Mouse
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SDS
PBS.pdf
Package List Price ($)
$ 399