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Integrin alpha 4 antibody [R1-2] (Azide free)

Cat. No. GTX75783

Reference 1

Host

 Rat

Clonality

 Monoclonal

Clone Name

 R1-2

Isotype

 IgG2b

Application

 IHC-Fr, FACS, IP, Functional Assay

Reactivity

 Mouse
Package
250 μg ($399)
See all Integrin alpha 4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
Functional Assay Assay dependent
Not tested in other applications.

Calculated MW

116 kDa. ( Note )

Product Note

This antibody recognizes an epitope within residues 195-268 of Integrin alpha 4. Clone R1-2 has been reported to inhibit the adhesion of murine lymphocytes to Peyer's patch HEV, (Holzmann et al. 1989)) and prevent central nervous system inflammation and experimental encephalomyelitis by inhibiting recruitment of inflammatory leukocytes (Brocke et al. 1999).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Lymphoma cell line TK1.

Purification

Protein G purified

Conjugation

Unconjugated

RRID

AB_378450

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

integrin alpha 4 , CD49D , Itga4B

Cellular Localization

Membrane; Single-pass type I membrane protein

Database

Research Area

REFERENCE

Application Reference

Kitai Y et al. Int Immunol 2021; (Epub) CD47 promotes T-cell lymphoma metastasis by upregulating AKAP13-mediated RhoA activation.
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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399
Custom Conjugations