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Integrin alpha 4 + beta 7 antibody [DATK32] (APC)

Anti-Integrin alpha 4 + beta 7 antibody [DATK32] (APC) used in Flow cytometry (FACS). GTX01493-07

Cat. No. GTX01493-07

Reference 3

Host

 Rat

Clonality

 Monoclonal

Clone Name

 DATK32

Isotype

 IgG2a

Application

 FACS

Reactivity

 Mouse
Package
100 μg ($259)
See all Integrin alpha 4 + beta 7 products
PRODUCT

Summary

The DATK32 antibody is specific for a combinatorial epitope of the mouse integrin αalpha 4/beta 7 (LPAM-1) heterodimer. LPAM-1 is expressed on most mature lymphocytes and sub-populations of thymocytes and bone marrow cells. It is involved in lymphocyte adhesion and migration and is a receptor for several extracellular matrix proteins including VCAM-1, fibronectin, and MAdCAM-1.DATK32 is reported to induce LPAM-1 dependent lymphocyte aggregation and block adhesion to VCAM-1, fibronectin, and MAdCAM-1.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
Not tested in other applications.

PROPERTIES

Form

Liquid

Buffer

10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Purification

Purified by affinity chromatography
From tissue culture supernatant

Conjugation

Allophycocyanin (APC)

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Cellular Localization

Membrane

Database

Research Area

DATA IMAGES

Anti-Integrin alpha 4 + beta 7 antibody [DATK32] (APC) used in Flow cytometry (FACS). GTX01493-07

GTX01493-07 FACS Image

FACS analysis of mouse C57Bl/6 bone marrow cells using GTX01493-07 Integrin alpha 4 + beta 7 antibody [DATK32] (APC).
Right panel : co-stained with Integrin alpha 4 + beta 7 antibody [DATK32] (APC) and Mouse CD45R antibody (FITC)
Left panel : co-stained with isotype control and Mouse CD45R antibody (FITC)
antibody amount : 0.25 μg (5 μl)

REFERENCE

Clone Reference

2000; Bidirectional induction of the cognate receptor-ligand alpha4/VCAM-1 pair defines a novel mechanism of tumor intravasation.
1994; Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation.
1993; Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.
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SDS
Sodium Azide.pdf
Package List Price ($)
$ 259