Integrin alpha 4 + beta 7 antibody [DATK32] (Biotin)

Cat. No. GTX01493-02
References 3
Cat. No.  GTX01493-02
Anti-Integrin alpha 4 + beta 7 antibody [DATK32] (Biotin) used in Flow cytometry (FACS). GTX01493-02
GTX01493-02 FACS Image

FACS analysis of mouse C57Bl/6 bone marrow cells using GTX01493-02 Integrin alpha 4 + beta 7 antibody [DATK32] (Biotin).
Right panel : co-stained with Integrin alpha 4 + beta 7 antibody [DATK32] (Biotin) and Mouse CD45R antibody (APC)
Left panel : co-stained with isotype control and Mouse CD45R antibody (APC)
antibody amount : 0.25 μg (5 μl)

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Anti-Integrin alpha 4 + beta 7 antibody [DATK32] (Biotin) used in Flow cytometry (FACS). GTX01493-02
  • Host
    Rat
  • Clonality
    Monoclonal
  • Clone Name
    DATK32
  • Isotype
    IgG2a
  • Applications
    FACS
  • Reactivity
    Mouse
Summary
The DATK32 antibody is specific for a combinatorial epitope of the mouse integrin αalpha 4/beta 7 (LPAM-1) heterodimer. LPAM-1 is expressed on most mature lymphocytes and sub-populations of thymocytes and bone marrow cells. It is involved in lymphocyte adhesion and migration and is a receptor for several extracellular matrix proteins including VCAM-1, fibronectin, and MAdCAM-1.DATK32 is reported to induce LPAM-1 dependent lymphocyte aggregation and block adhesion to VCAM-1, fibronectin, and MAdCAM-1.
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