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Integrin alpha 5 antibody [JBS5]

Cat No. GTX74715

Host

Mouse

Clonality

Monoclonal

Clone Name

JBS5

Isotype

IgG1

Application

IHC-Fr, FACS, IP, Activation, Neutralizing/Inhibition

Reactivity

Human, Dog
Package
100 μg ($289)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-Fr 0.5-1μg/ml
FACS Neat-1/10
IP 1-5μg/ml
Activation Assay dependent
Neutralizing/Inhibition Assay dependent

Note :

FACS
Use 20μl of the suggested working dilution to label 5 x 105 cells or 100μl of whole blood.

Activation
Mouse anti human CD49e antibody, clone JBS5 been shown to stimulate homotypic cellular aggregation of alpha 5 beta 1 positive lymphoid cell lines (Shen et al. 1991). It also inhibits the adherence of cells to fibronectin.

Not tested in other applications.

Calculated MW

115 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 0.09% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Integrin Subunit Alpha 5 , Cd49E , Fnra , Vla-5 , Vla5A , Itga5

Background

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015]

Database

Research Area

REFERENCE

There are currently no references for Integrin alpha 5 antibody [JBS5] (GTX74715). Be the first to share your publications with this product.

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 289