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Integrin alpha 6 antibody [450-30A]

Anti-Integrin alpha 6 antibody [450-30A] used in Flow cytometry (FACS). GTX75046
Anti-Integrin alpha 6 antibody [450-30A] used in Flow cytometry (FACS). GTX75046
Anti-Integrin alpha 6 antibody [450-30A] used in Western Blot (WB). GTX75046

Cat. No. GTX75046

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 450-30A

Isotype

 IgG1

Application

 WB, IHC-Fr, FACS

Reactivity

 Human
Package
100 μg ($349)
See all Integrin alpha 6 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-Fr 1/50-1/100
FACS 1/10-1/50

Note :

IHC-Fr
The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. Recommend the use of acetone fixation for frozen sections.

FACS
Use 10μl of the suggested working dilution to label 106 cells in 100μl.
Not tested in other applications.

Calculated MW

127 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

integrin a6b4 purified from A431 cells

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_376584

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

integrin subunit alpha 6 , CD49f , ITGA6B , VLA-6

Cellular Localization

Cell membrane

Background

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Database

Research Area

DATA IMAGES

Anti-Integrin alpha 6 antibody [450-30A] used in Flow cytometry (FACS). GTX75046

GTX75046 FACS Image

FACS analysis of human peripheral blood lymphocytes using GTX75046 Integrin alpha 6 antibody [450-30A].

Anti-Integrin alpha 6 antibody [450-30A] used in Flow cytometry (FACS). GTX75046

GTX75046 FACS Image

FACS analysis of human peripheral blood monocytes using GTX75046 Integrin alpha 6 antibody [450-30A].

Anti-Integrin alpha 6 antibody [450-30A] used in Western Blot (WB). GTX75046

GTX75046 WB Image

WB analysis of Jurkat cell lysate using GTX75046 Integrin alpha 6 antibody [450-30A].

REFERENCE

Clone Reference

Lee TC et al. PLoS One 2014; 9 (11):e111390 Comparison of Surface Markers between Human and Rabbit Mesenchymal Stem Cells.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 349