GeneTex
United States (US)

Integrin beta 1 / CD29 antibody [MEM-101A]

Integrin-beta-1-antibody-MEM-101A__GTX28238-1_18121411_692.jpg

Cat No. GTX28238

Host Mouse
Clonality Monoclonal
Clone Name MEM-101A
Isotype IgG1
Application WB, FACS, IP
Reactivity Human, Dog, Pig
APPLICATION

Application Note

FACS: Use at an assay dependent concentration. IP: Use at an assay dependent concentration. WB: Use at an assay dependent concentration. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

88 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Phosphate buffered saline pH 7.4 containing 15mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Tissue / cell preparation (Human). (Burkitts lymphoma cell line Raji).

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Integrin beta 1, Integrin beta1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, VLA BETA, VLABETA

Background

Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6, also known as CD49a, CD49b, CD49c, CD49d, CD49e, and CD49f, respectively) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrins on the cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.

Database

Research Area

DATA IMAGES
Integrin-beta-1-antibody-MEM-101A__GTX28238-1_18121411_692.jpg

GTX28238 WB Image

Western Blot analysis (non-reducing conditions) of isolated peripheral blood lymphocytes of various species using anti-Integrin beta 1 (GTX28238)
Lane 1: lysate of human PBL
Lane 2: lysate of canine PBL
Lane 3: lysate of porcine PBL

Package List Price ($)
$ 319