GeneTex
United States (US)

JAK1 antibody [7G6]

GTX34019_20170112_IHC-P_1_18121410_534.jpg
GTX34019_20170112_IHC-P_18121410_678.jpg

Cat No. GTX34019

Host Mouse
Clonality Monoclonal
Clone Name 7G6
Isotype IgG1
Application IHC-P
Reactivity Human, Mouse, Rat
APPLICATION

Calculated MW

133 kDa. ( Note )

Specificity/Sensitivity

JAK1 Mouse Monoclonal Antibody (7G6) detects endogenous levels of JAK1
PROPERTIES

Form

Liquid

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Synthetic Peptide of JAK1

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Janus Kinase 1,Jak1A,Jak1B,Jtk3,Jak1

Background

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX34019_20170112_IHC-P_1_18121410_534.jpg

GTX34019 IHC-P Image

Immunohistochemistry (IHC) analysis of paraffin-embedded Human Breast Carcinoma Tissue using JAK1 Mouse Monoclonal Antibody diluted at 1:200.

GTX34019_20170112_IHC-P_18121410_678.jpg

GTX34019 IHC-P Image

Immunohistochemistry (IHC) analysis of paraffin-embedded Human Lung Carcinoma Tissue using JAK1 Mouse Monoclonal Antibody diluted at 1:200.

Package List Price ($)
$ 319