JAK2 (phospho Tyr1007/1008) antibody

Name: JAK2 (phospho Tyr1007/1008) antibody
Brand: GeneTex
SKU: GTX132784
Price: 399.00 USD
Rating: 5 (1 reviews)

Anti-JAK2 (phospho Tyr1007/1008) antibody used in Western Blot (WB). GTX132784

Cat. No. GTX132784

Reference 6

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB
Reactivity	Human, Mouse
Package	100 μl ($399), 25 μl ($169)

See all JAK2 products

View product citations for antibody GTX132784 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:500-1:3000

Not tested in other applications.

Calculated MW

131 kDa. ( Note )

Positive Control

K562

Predict Reactivity

Rat, Chicken, Pig, Xenopus tropicalis, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.25 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide surrounding phospho Tyr1007/Tyr1008 of human JAK2. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_2886741

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Janus kinase 2 , JTK10 , THCYT3

Cellular Localization

Endomembrane system; Peripheral membrane protein

Background

This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq]

Database

Gene ID: 3717 JAK2
UniProt: O60674 JAK2

Research Area

DATA IMAGES

GTX132784 WB Image

Untreated (–) and treated (+) K562 whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with JAK2 (phospho Tyr1007/1008) antibody (GTX132784) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

GTX132784 WB Image

The data was published in the 2019 in J Exp Clin Cancer Res. PMID: 30961670

REFERENCE

Application Reference

Shen Y et al. Molecules 2023; 29 (1) Transformation of Ginsenosides by Lactiplantibacillus plantarum MB11 Fermentation: Minor Ginsenosides Conversion and Enhancement of Anti-Colorectal Cancer Activity.

Yunjiao Shen et al. Authorea. 2023; Transformation of ginsenosides by Lactiplantibacillus plantarum MB11 fermentation: minor ginsenosides conversion and enhancement of anti-colorectal cancer activity

Application : WB

Li CJ et al. J Hepatocell Carcinoma 2023; 10 : 123-138

Application : WB

Reactivity : Human

Lin ZH et al. J Ethnopharmacol 2022; 282 : 114636 Water extract of medicinal ink (WEMI) attenuates lipopolysaccharide-induced NO production of Raw264.7 cells via downregulating JAK2/STAT3-mediated iNOS expression.

Application : WB

Reactivity : Mouse

Shen M et al. J Exp Clin Cancer Res 2019; 38 (1) : 149

Application : WB

Reactivity : Human

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