GeneTex
United States (US)

JAM-A antibody, C-term

GTX88380_2376_WB_18122102_928.jpg

Cat No. GTX88380

Host Goat
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.3-2μg/ml
Not tested in other applications.

Calculated MW

33 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX88380-PEP).

Predict Reactivity

Mouse, Rat, Dog, Pig(>80% identity)
PROPERTIES

Form

Liquid

Buffer

Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.

Concentration

0.50mg/ml

Antigen Species

Human

Immunogen

Peptide with sequence C-QPSARSEGEFKQTS, from the C Terminus of the protein sequence according to NP_058642.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

KAT Antibody , F11R Antibody , JAM1 Antibody , JAMA Antibody , JAM Antibody , JCAM Antibody , PAM1 Antibody , CD321 Antibody

Cellular Localization

Localized at tight junctions of both epithelial and endothelial cells.

Background

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
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Database

Research Area

DATA IMAGES
GTX88380_2376_WB_18122102_928.jpg

GTX88380 WB Image

WB analysis of human peripheral blood mononucleocyte lysate using GTX88380 JAM-A antibody, C-term.
Dilution : 0.3µg/ml
Loading : 35µg protein in RIPA buffer