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JIP1 antibody

Anti-JIP1 antibody used in Western Blot (WB). GTX100604
Anti-JIP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100604
Anti-JIP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100604

Cat No. GTX100604

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse
Package
100 μl ($319),
25 μl ($169)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

78 kDa. ( Note )

Positive Control

HepG2

Predict Reactivity

Rat, Bovine(>80% identity)
PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human JIP1. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

mitogen-activated protein kinase 8 interacting protein 1,IB1,JIP-1,JIP1,PRKM8IP

Cellular Localization

Cytoplasm , Cytoplasm , perinuclear region , Nucleus

Background

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq]

Database

Research Area

DATA IMAGES
Anti-JIP1 antibody used in Western Blot (WB). GTX100604

GTX100604 WB Image

Sample(30 ug whole cell lysate)
A:Hep G2 (GTX27900)
7.5% SDS PAGE
GTX100604 diluted at 1:1000

Anti-JIP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100604

GTX100604 IHC-P Image

Immunohistochemical analysis of paraffin-embedded lung SCC xenograft, using MAPK8IP1(GTX100604) antibody at 1:100 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-JIP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX100604

GTX100604 IHC-P Image

JIP1 antibody detects JIP1 protein at cytoplasm on mouse brain by immunohistochemical analysis.
Sample: Paraffin-embedded mouse brain.
JIP1 antibody (GTX100604) diluted at 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

REFERENCE
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REVIEW
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SDS
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 319
$ 169