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JPH2 antibody

Anti-JPH2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85364
Anti-JPH2 antibody used in Western Blot (WB). GTX85364

Cat. No. GTX85364

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all JPH2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

74 kDa. ( Note )

Positive Control

Mouse Brain Tissue Lysate(GTX27934)

Product Note

This antibody is specific for JPH2 C-Terminus

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

JPH2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human JPH2.The immunogen is located within amino acids 470 - 520 of JPH2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

junctophilin 2 , CMH17 , JP-2 , JP2

Cellular Localization

Endoplasmic reticulum membrane

Background

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH2- mice died of embryonic cardiac arrest and human patients with mutations in the JPH2 gene showed hypertrophic cardiomyopathy, demonstrating the importance of this protein. Multiple isoforms of JPH2 are known to exist.

Database

Research Area

DATA IMAGES

Anti-JPH2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85364

GTX85364 IHC-P Image

IHC-P analysis of mouse skeletal muscle tissue using GTX85364 JPH2 antibody.
Working concentration : 2.5 μg/ml

Anti-JPH2 antibody used in Western Blot (WB). GTX85364

GTX85364 WB Image

WB analysis of mouse brain tissue lysate using GTX85364 JPH2 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399