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Jab1 antibody [6C3.38]

Anti-Jab1 antibody [6C3.38] used in Immunohistochemistry (IHC). GTX70205

Cat. No. GTX70205

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 6C3.38

Isotype

 IgG2a

Application

 WB, IP, IHC

Reactivity

 Human, Mouse
Package
100 μl ($399)
See all Jab1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5 - 1 μg/ml
IP 0.5 - 1 μg/ml
IHC Assay dependent
Not tested in other applications.

Calculated MW

38 kDa. ( Note )

Positive Control

293 cell lysate

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No Preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

The full-length mouse JAB-1 gene expressed in E. coli.

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_371980

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

COP9 signalosome subunit 5 , CSN5 , JAB1 , MOV-34 , SGN5

Cellular Localization

Cytoplasm, cytosol , Nucleus

Background

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Jab1 antibody [6C3.38] used in Immunohistochemistry (IHC). GTX70205

GTX70205 IHC Image

REFERENCE

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REVIEW

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Package List Price ($)
$ 399
Custom Conjugations