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Jab1 antibody [8H8.5]

Anti-Jab1 antibody [8H8.5] used in Western Blot (WB). GTX70207
Anti-Jab1 antibody [8H8.5] used in Western Blot (WB). GTX70207
Anti-Jab1 antibody [8H8.5] used in Western Blot (WB). GTX70207

Cat No. GTX70207

Host

Mouse

Clonality

Monoclonal

Clone Name

8H8.5

Isotype

IgG2a

Application

WB, IP

Reactivity

Human, Mouse, Drosophila
Package
100 μl ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

38 kDa. ( Note )

Positive Control

293 cell lysate

PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4, containing no preservatives

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

The full-length mouse JAB-1 gene expressed in E. coli.

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Cop9 Signalosome Subunit 5 , Csn5 , Jab1 , Mov-34 , Sgn5 , Cops5

Cellular Localization

Nuclear/Cytoplasmic

Background

JAB-1 is a 38a protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the ""Signalosome"", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.

Database

Research Area

DATA IMAGES

Anti-Jab1 antibody [8H8.5] used in Western Blot (WB). GTX70207

GTX70207 WB Image

Part of a customer review using GTX70207

Anti-Jab1 antibody [8H8.5] used in Western Blot (WB). GTX70207

GTX70207 WB Image

Detection of human Jab1 protein in HeLa whole cell lysate using GeneTex monoclonal antibody GTX70207

Anti-Jab1 antibody [8H8.5] used in Western Blot (WB). GTX70207

GTX70207 WB Image

Customer Review using GTX70207 - D10 T cells were lysed in IP buffer (20mM Tris-HCl, pH 7.5, 50mM NaCl, 50mM NaF, 10mM -glycerophosphate, 1% Triton X-100, 1mM PMSF).

REFERENCE

REVIEW

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