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Jagged 1 antibody [4A24]

Cat. No. GTX52879

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4A24

Isotype

 IgG2

Application

 WB, FACS, Neutralizing/Inhibition

Reactivity

 Human
Package
100 μg ($399)
See all Jagged 1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:1000
FACS 1:50 - 1:200
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

134 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

500 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human recombinant Jagged-1

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_2887808

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

AGS , AGS1 , AHD , AWS , CD339 , HJ1 , JAG1 , JAGL1 , jagged 1 , Jagged 1 , Jagged1 , jagged canonical Notch ligand 1

Cellular Localization

Membrane

Background

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Application Reference

Yang GC et al. Stem Cells Int 2015; 2015 : 162410 Acute Lymphoblastic Leukemia Cells Inhibit the Differentiation of Bone Mesenchymal Stem Cells into Osteoblasts In Vitro by Activating Notch Signaling.
Application : Neutralizing/Inhibition
Reactivity : Human
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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399