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Jagged 1 antibody

Anti-Jagged 1 antibody used in Western Blot (WB). GTX31607
Anti-Jagged 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31607
Anti-Jagged 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31607

Cat. No. GTX31607

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($419)
See all Jagged 1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

134 kDa. ( Note )

Positive Control

Human Spleen Tissue Slide , HeLa Cell Lysate

Product Note

At least two isoforms of JAG1 are known to exist; this antibody will detect both isoforms.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

JAG1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human JAG1.The immunogen is located within the last 50 amino acids of JAG1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

jagged canonical Notch ligand 1 , AGS , AGS1 , AHD , AWS , CD339 , DCHE , HJ1 , JAGL1

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Jagged 1 antibody used in Western Blot (WB). GTX31607

GTX31607 WB Image

WB analysis of HeLa cell lysate using GTX31607 Jagged 1 antibody.
Working concentration : 1 μg/ml

Anti-Jagged 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31607

GTX31607 IHC-P Image

IHC-P analysis of human spleen tissue using GTX31607 Jagged 1 antibody.
Working concentration : 5 μg/ml

Anti-Jagged 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31607

GTX31607 IHC-P Image

IHC-P analysis of human spleen tissue using GTX31607 Jagged 1 antibody.
Working concentration : 20 μg/ml

REFERENCE

Application Reference

Vadhan A et al. Oncol Lett 2023; 25 (1) : 42 Fumarate hydratase inhibits non-small cell lung cancer metastasis via inactivation of AMPK and upregulation of DAB2.
Application : WB
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 419