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KA1 antibody

Anti-KA1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85044
Anti-KA1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85044
Anti-KA1 antibody used in Western Blot (WB). GTX85044

Cat No. GTX85044

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P, ELISA

Reactivity

Human, Mouse, Rat
Package
100 μg ($409)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5 - 2 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

107 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , Rat Brain Tissue Lysate(GTX27942)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KA1 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of the human KA1.The immunogen is located within amino acids 30 - 80 of KA1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

glutamate ionotropic receptor kainate type subunit 4 , EAA1 , GRIK , GluK4 , KA1

Cellular Localization

Cell membrane; Multi-pass membrane protein

Background

Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE.

Database

Research Area

DATA IMAGES

Anti-KA1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85044

GTX85044 IHC-P Image

IHC-P analysis of human brain tissue using GTX85044 KA1 antibody.
Working concentration : 2.5 μg/ml

Anti-KA1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85044

GTX85044 IHC-P Image

IHC-P analysis of human brain tissue using GTX85044 KA1 antibody.
Working concentration : 20 μg/ml

Anti-KA1 antibody used in Western Blot (WB). GTX85044

GTX85044 WB Image

WB analysis of rat brain tissue lysate using GTX85044 KA1 antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml

REFERENCE

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409