APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 0.5 - 2 μg/mL |
| 2.5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Human Brain Tissue Slide(GTX22203) , Rat Brain Tissue Lysate(GTX27942)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
KA1 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of the human KA1.The immunogen is located within amino acids 30 - 80 of KA1.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
glutamate ionotropic receptor kainate type subunit 4 , EAA1 , GRIK , GluK4 , KA1
Cellular Localization
Cell membrane; Multi-pass membrane protein
Background
Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE.
Database
Research Area
DATA IMAGES
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GTX85044 IHC-P Image
IHC-P analysis of human brain tissue using GTX85044 KA1 antibody.
Working concentration : 2.5 μg/ml
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GTX85044 IHC-P Image
IHC-P analysis of human brain tissue using GTX85044 KA1 antibody.
Working concentration : 20 μg/ml
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GTX85044 WB Image
WB analysis of rat brain tissue lysate using GTX85044 KA1 antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml
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REFERENCE
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REVIEW
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