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KCNN3 antibody, C-term

Anti-KCNN3 antibody, C-term used in Western Blot (WB). GTX47693
Anti-KCNN3 antibody, C-term used in Western Blot (WB). GTX47693
Anti-KCNN3 antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX47693
Anti-KCNN3 antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX47693

Cat. No. GTX47693

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Monkey
Package
50 μg ($409)
See all Kcnn3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.2-2.5 ug/ml
IHC-P 2-10 ug/ml
Not tested in other applications.

Calculated MW

81 kDa. ( Note )

Positive Control

Daudi , mouse brain

PROPERTIES

Form

Liquid

Buffer

PBS, 2% Sucrose

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a C-terminal region of Human KCNN3

Purification

Affinity Purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

potassium calcium-activated channel subfamily N member 3 , KCa2.3 , SK3 , SKCA3 , hSK3

Cellular Localization

Membrane; Multi-pass membrane protein

Background

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Database

Research Area

DATA IMAGES

Anti-KCNN3 antibody, C-term used in Western Blot (WB). GTX47693

GTX47693 WB Image

WB analysis of mouse brain and kidney tissue using GTX47693 KCNN3 antibody at 2μg/ml.
Lane l : Mouse kidney (negative control)
Lane 2: Mouse whole brain (positive control)

Anti-KCNN3 antibody, C-term used in Western Blot (WB). GTX47693

GTX47693 WB Image

WB analysis of Daudi cells using GTX47693 KCNN3 antibody at 0.2-1μg/ml.

Anti-KCNN3 antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX47693

GTX47693 IHC-P Image

IHC-P analysis of Rhesus macaque spinal cord tissue using GTX47693 KCNN3 antibody at 1:300.

Anti-KCNN3 antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX47693

GTX47693 IHC-P Image

IHC-P analysis of human heart tissue using GTX47693 KCNN3 antibody at 1:600. Left to right:DAPI, KCNN3, Merge. Low pH, heat-induced antigen retrieval method utilizing Sodium Citrate buffer.

REFERENCE

Application Reference

Wen-Tao Sun et al. Ann Transl Med 2021; 9 (8) : 625 Homocysteine alters vasoreactivity of human internal mammary artery by affecting the KCa channel family.
Application : WB
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409