APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:2,000 |
| 1:100 |
Not tested in other applications.
Calculated MW
Positive Control
PC12, rat cerebellum
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
15mM Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Mouse
Immunogen
synthetic peptide corresponding to the C-terminus of mouse KIF3A (amino acids 682-701) conjugated to KLH.
Purification
IgG fraction
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
kinesin family member 3A , FLA10 , KLP-20
Cellular Localization
Cytoplasm, cytoskeleton
Background
The kinesin superfamily (KIFs) of proteins consists of a class of microtubule-dependent motors that plays a major role in many cellular and developmental functions, including organelle transport, mitosis, meiosis, and possibly long-range signaling in neurons. The KIF proteins are primarily associated with anterograde transport of vesicles and organelles in neurons, epithelial cells, and melanosomes with bidirectional transport of mitochondria and mediating transport between the endoplasmic reticulum (ER) and the Golgi complex. KIF3 motor complex is composed of the KIF3A, KIF3B, and KIF3C motor subunits, that associate as heterodimers, in which KIF3B and KIF3C are alternative partners of KIF3A. KIF3A/B has been shown to function in vivo as a motor for the anterograde fast axonal transport of membranebound organelles in neurons. KIF3 plays a crucial role during development. KIF3A-/- and KIF3B-/- mice do not survive beyond midgestation.
Database
Research Area
DATA IMAGES
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GTX11259 IHC-P Image
IHC-P analysis of rat brain tissue using GTX11259 KIF3A antibody at 0.1 μg/mL.
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GTX11259 IHC-P Image
IHC-P analysis of mouse brain tissue using GTX11259 KIF3A antibody at 0.4 μg/mL.
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GTX11259 IHC-P Image
IHC-P analysis of rat brain tissue using GTX11259 KIF3A antibody at 0.1 μg/mL.
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GTX11259 IHC-P Image
IHC-P analysis of mouse brain tissue using GTX11259 KIF3A antibody at 0.4 μg/mL.
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REFERENCE
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REVIEW
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