APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 - 2 μg/mL |
| 20 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
HEK293 Cell Slide(GTX25524) , HEK293 Cell Lysate(GTX27902)
Product Note
KIR2DS2 antibody is human specific. Multiple isoforms are known to exist.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
KIR2DS2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KIR2DS2.The immunogen is located within the last 50 amino acids of KIR2DS2.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 , 183ActI , CD158J , CD158b , KIR-2DS2 , NKAT-5 , NKAT5 , cl-49
Cellular Localization
Cell membrane; Single-pass type I membrane protein
Background
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are
Database
Research Area
DATA IMAGES
|
GTX31949 ICC/IF Image
ICC/IF analysis of HEK293 cells using GTX31949 KIR2DS2 antibody.
Green : Primary antibody
Blue : DAPI
Dilution : 20 μg/ml
|
|
|
GTX31949 ICC/IF Image
ICC/IF analysis of 293 cells using GTX31949 KIR2DS2 antibody.
Working concentration : 20 μg/ml
|
|
|
GTX31949 ICC/IF Image
ICC/IF analysis of HEK293 cells using GTX31949 KIR2DS2 antibody.
Dilution : 5 μg/ml
|
|
|
GTX31949 WB Image
WB analysis of 293 cell lysate using GTX31949 KIR2DS2 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml
|
REFERENCE
There are currently no references for KIR2DS2 antibody (GTX31949). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for KIR2DS2 antibody (GTX31949). Be the first to share your experience with this product.
