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KIR3DL1 antibody [1L34]

Cat No. GTX52898

Host

Mouse

Clonality

Monoclonal

Clone Name

1L34

Isotype

IgG1

Application

FACS, Neutralizing/Inhibition

Reactivity

Human
Package
100 μg ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
FACS 1:50 - 1:100
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

49 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

500 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human recombinant KIR3DL1

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CD158E1 , KIR , KIR3DL1 , KIR3DL1/S1 , KIR3DL2 , NKAT3 , NKB1 , NKB1B , killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1

Cellular Localization

Cell membrane

Background

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

There are currently no references for KIR3DL1 antibody [1L34] (GTX52898). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for KIR3DL1 antibody [1L34] (GTX52898). Be the first to share your experience with this product.
SDS
PBS.pdf
Package List Price ($)
$ 329