APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
1:200-1:1000 |
1:200-1:400 |
1:10,000 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.05% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Purified recombinant fragment of human KIR3DL1 (AA: extra 22-340) expressed in HEK293 cells.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
CD158E1 , KIR , KIR3DL1 , KIR3DL1/S1 , KIR3DL2 , NKAT3 , NKB1 , NKB1B , killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1
Cellular Localization
Cell membrane
Background
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX00648 FACS Image
FACS analysis of Jurkat cells using GTX00648 KIR3DL1 antibody. Green : Primary antibody Red : Negative control
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GTX00648 WB Image
WB analysis of human KIR3DL1 recombinant protein (AA: extra 22-340) using GTX00648 KIR3DL1 antibody. Expected MW : 65 kDa
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GTX00648 WB Image
WB analysis of various samples using GTX00648 KIR3DL1 antibody. Lane 1 : A431 whole cell lysate Lane 2 : Raji whole cell lysate Lane 3 : SPC-A-1 whole cell lysate Lane 4 : K562 whole cell lysate Lane 5 : HEK293 whole cell lysate Lane 6 : U937 whole cell lysate Lane 7 : C6 whole cell lysate
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GTX00648 ELISA Image
ELISA analysis of antigen using GTX00648 KIR3DL1 antibody. Black : Control Antigen (100 ng) Purple : Antigen (10ng) Blue : Antigen (50 ng) Red Antigen (100 ng)
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REFERENCE
There are currently no references for KIR3DL1 antibody [6D9A4] (GTX00648). Be the first to share your publications with this product.
REVIEW
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