APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
0.1-0.3μg/ml |
3-5μg/ml |
Note :
IHC-P
Human Pancreas shows variable staining across the islet of Langerhans.
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Not tested in other applications.
Positive Control
The peptide used to generate this antibody is available for purchase (GTX88908-PEP).
Product Note
This antibody is expected to recognise isoform 1 (NP_000516.3) only.
PROPERTIES
Form
Liquid
Buffer
TBS, 0.5% BSA
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.50 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Peptide with sequence C-AEDPAKPRYRARQ, from the internal region (near the N Terminus) of the protein sequence according to NP_000516.3.
Purification
Purified by ammonium sulphate precipitation followed by antigen affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
Potassium Voltage-Gated Channel Subfamily J Member 11 , Bir , Hhf2 , Ikatp , Kir6.2 , Mody13 , Phhi , Tndm3 , Kcnj11
Background
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]
Research Area
DATA IMAGES
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GTX88908 IHC-P Image
IHC-P analysis of human pancreas using GTX88908 Kir6.2 antibody, Internal (near the N-term). Antigen retrieval : citrate buffer pH 6 Dilution : 3.8μg/ml
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GTX88908 WB Image
WB analysis of human muscle lysate using GTX88908 Kir6.2 antibody, Internal (near the N-term). Dilution : 0.1μg/ml Loading : 35μg protein in RIPA buffer
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REFERENCE
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REVIEW
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