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Kir6.2 antibody

Anti-Kir6.2 antibody used in Western Blot (WB). GTX66690
Anti-Kir6.2 antibody used in IHC (Paraffin sections) (IHC-P). GTX66690

Cat No. GTX66690

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human, Mouse, Rat
Package
100 μl ($349)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IHC-P 1:50-1:200
Not tested in other applications.

Calculated MW

44 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH7.2, 0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide, corresponding to amino acids 188-243 of Human Kir6.2.

Purification

Purified by antigen-affinity chromatography
From serum

Purity

> 95% (by SDS-PAGE)

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

potassium voltage-gated channel subfamily J member 11 , BIR , HHF2 , IKATP , KIR6.2 , MODY13 , PHHI , TNDM3

Cellular Localization

Membrane; Multi-pass membrane protein

Background

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]

Database

Research Area

DATA IMAGES

Anti-Kir6.2 antibody used in Western Blot (WB). GTX66690

GTX66690 WB Image

WB analysis of various samples using GTX66690 Kir6.2 antibody.
Lane1 : HEK293T whole cell lysate
Lane2 : Raw264.7 whole cell lysate
Lane3 : PC12 whole cell lysate
Dilution : 1:500

Anti-Kir6.2 antibody used in IHC (Paraffin sections) (IHC-P). GTX66690

GTX66690 IHC-P Image

IHC-P analysis of human brain tissue using GTX66690 Kir6.2 antibody.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf