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Klotho antibody, Internal

Anti-Klotho antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX89443
Anti-Klotho antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX89443

Cat. No. GTX89443

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all Klotho products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 4-6μg/ml

Note :

IHC-P
Human Breast shows cytoplasm staining in luminal epithelial cells of ducts, while Human Placenta shows membranous staining.
Not tested in other applications.

Calculated MW

116 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX89443-PEP).

Product Note

This antibody is expected to recognise both reported isoforms (NP_004786.2; NP_710150.1).

Predict Reactivity

Mouse, Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

TBS, 0.5% BSA

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide with sequence C-KRDDAKYMYYLKK, from the internal region of the protein sequence according to NP_004786.2; NP_710150.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

klotho , HFTC3

Cellular Localization

Apical cell membrane

Background

This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Klotho antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX89443

GTX89443 IHC-P Image

IHC-P analysis of human placenta using GTX89443 Klotho antibody, Internal.
Antigen retrieval : citrate buffer pH 6
Dilution : 4μg/ml

Anti-Klotho antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX89443

GTX89443 IHC-P Image

IHC-P analysis of human breast using GTX89443 Klotho antibody, Internal.
Antigen retrieval : citrate buffer pH 6
Dilution : 4μg/ml

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399