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Klotho antibody

Anti-Klotho antibody used in IHC (Paraffin sections) (IHC-P). GTX17093
Anti-Klotho antibody used in IHC (Paraffin sections) (IHC-P). GTX17093
Anti-Klotho antibody used in Western Blot (WB). GTX17093
Anti-Klotho antibody used in IHC (Paraffin sections) (IHC-P). GTX17093

Cat. No. GTX17093

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all Klotho products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

116 kDa. ( Note )

Positive Control

HepG2 Cell Lysate(GTX27900)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLOTHO antibody was raised against a 16 amino acid synthetic peptide near the center of human KLOTHO.The immunogen is located within amino acids 410 - 460 of KLOTHO.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

RRID

AB_2887552

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

klotho , HFTC3

Cellular Localization

Apical cell membrane

Background

This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Klotho antibody used in IHC (Paraffin sections) (IHC-P). GTX17093

GTX17093 IHC-P Image

IHC-P analysis of mouse heart tissue using GTX17093 Klotho antibody.
Working concentration : 20 μg/ml

Anti-Klotho antibody used in IHC (Paraffin sections) (IHC-P). GTX17093

GTX17093 IHC-P Image

IHC-P analysis of rat heart tissue using GTX17093 Klotho antibody.
Working concentration : 2.5 μg/ml

Anti-Klotho antibody used in Western Blot (WB). GTX17093

GTX17093 WB Image

WB analysis of HepG2 cell lysate using GTX17093 Klotho antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

Anti-Klotho antibody used in IHC (Paraffin sections) (IHC-P). GTX17093

GTX17093 IHC-P Image

IHC-P analysis of mouse heart tissue using GTX17093 Klotho antibody.
Working concentration : 2.5 μg/ml

REFERENCE

Application Reference

Youssef OM et al. J Chem Neuroanat 2020; 108 : 101803 The neuroprotective effect of simvastatin on the cerebellum of experimentally-induced diabetic rats through klotho upregulation: An immunohistochemical study.
Application : IHC-P
Reactivity : Rat
Wada E et al. J Physiol Sci 2019; 69 (4) : 661-671 Renal involvement in the pathogenesis of mineral and bone disorder in dystrophin-deficient mdx mouse.
Application : WB
Reactivity : Mouse
Submit a Reference

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399