APPLICATION
Application Note
For WB: Use at a dilution of 1:2,500. Optimal dilutions/concentrations should be determined by the researcher.
Calculated MW
Positive Control
HeLa, Raji
PROPERTIES
Form
Liquid
Buffer
Serum diluted with PBS pH7.4
Preservative
No Preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Antigen Species
Human
Immunogen
Recombinant antigen containing the amino terminal portion of human Ku70 protein
Purification
Unpurified
Conjugation
Unconjugated
RRID
AB_372046
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
X-ray repair cross complementing 6 , CTC75 , CTCBF , G22P1 , KU70 , ML8 , TLAA
Cellular Localization
Nucleus
Background
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX70259 WB Image
GTX70259 at a 1:2500 dilution staining Ku 70 in A) HeLa whole cell extract and B) Raji whole cell extract by Western Blot (ECL).
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REFERENCE
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REVIEW
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