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Ku70 antibody

Anti-Ku70 antibody used in Western Blot (WB). GTX70270

Cat No. GTX70270

Reference 1

Host

 Mouse

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human
Package
100 μl ($329)
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APPLICATION

Application Note

For WB: Use at a dilution of 1:1,000. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

70 kDa. ( Note )

Positive Control

HeLa, Raji

PROPERTIES

Form

Liquid

Buffer

Antiserum diluted in PBS pH 7.4, containing no preservatives

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant antigen containing the amino terminal portion of human Ku70 protein

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

X-Ray Repair Cross Complementing 6 , Ctc75 , Ctcbf , G22P1 , Ku70 , Ml8 , Tlaa , Xrcc6

Cellular Localization

Nuclear

Background

Originally identified as an autoantigen, the Ku protein are nuclear proteins found in eukaryotes. They exist as a heterodimer consisiting of Ku 70 and Ku 80, migrating at approximately 70 and 80 kDa respectively. They bind to DNA ends at double strand breaks. The Ku proteins interact with the DNA-dependent protein kinase (DNA-PK) and participate in the targeting of DNA-PK to DNA. The Ku proteins may participate in numerous cellular processes, including DNA repair and replication, cell signalling, cell proliferation, transcriptional activation and apoptosis.

Database

Research Area

DATA IMAGES

Anti-Ku70 antibody used in Western Blot (WB). GTX70270

GTX70270 WB Image

Detection of human Ku70 protein by Western Blot using GeneTex Ku70 polyclonal antiserum (GTX70270) in HeLa whole cell extract (lane 1) and Raji whole cell lysate (lane 2).

REFERENCE

Application Reference

Keka IS et al. Nucleic Acids Res 2015; 43 (13) : 6359-72 Smarcal1 promotes double-strand-break repair by nonhomologous end-joining.
Application : WB
Reactivity : Human
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SDS
PBS.pdf
Package List Price ($)
$ 329