Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Antigen Species
Human
Immunogen
Recombinant antigen containing the amino terminal portion of human Ku70 protein
Purification
Unpurified
Conjugation
Unconjugated
RRID
AB_372047
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
Detection of human Ku70 protein by Western Blot using GeneTex Ku70 polyclonal antiserum (GTX70270) in HeLa whole cell extract (lane 1) and Raji whole cell lysate (lane 2).
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GTX70270 WB Image
The data was published in the journal Nucleic Acids Res in 2015.PMID: 26089390