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Ku80 antibody

Cat No. GTX70273

Host

Mouse

Clonality

Polyclonal

Isotype

IgG

Application

WB

Reactivity

Human
Package
50 μl ($319)

APPLICATION

Application Note

For WB: Use at a dilution of 1:1,000. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

83 kDa. ( Note )

Positive Control

HeLa, Raji

PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4, containing no preservatives

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant antigen containing the amino terminal portion of human Ku80 protein

Purification

Mouse Polyclonal Antiserum
Antiserum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

X-Ray Repair Cross Complementing 5 , Karp-1 , Karp1 , Ku80 , Kub2 , Ku86 , Nfiv , Xrcc5

Background

Originally identified as an autoantigen, the Ku protein are nuclear proteins found in eukaryotes. They exist as a heterodimer consisiting of Ku 70 and Ku 80, migrating at approximately 70 and 80 kDa respectively. They bind to DNA ends at double strand breaks. The Ku proteins interact with the DNA-dependent protein kinase (DNA-PK) and participate in the targeting of DNA-PK to DNA. The Ku proteins may participate in numerous cellular processes, including DNA repair and replication, cell signalling, cell proliferation, transcriptional activation and apoptosis.

Database

Research Area

REFERENCE

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Package List Price ($)
$ 319