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Ku80 antibody

Anti-Ku80 antibody used in Western Blot (WB). GTX70485
Anti-Ku80 antibody used in Western Blot (WB). GTX70485

Cat No. GTX70485

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ELISA

Reactivity

Human, Mouse
Package
100 μg ($289)

APPLICATION

Application Note

Western blot - Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Specificity/Sensitivity

Reacts with residues 323-338 [FSKVDEEQMKYKSEGK] of the 80 kDa Ku80 protein. Sequence is 100% conserved between human, mouse rat and hamster.

PROPERTIES

Form

Liquid

Buffer

PBS containing 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Purification

Affinity purified IgG

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Background

Telomere length maintenance, an activity essential for chromosome stability and genome integrity, is regulated by telomerase- and telomere-associated factors. The DNA repair protein Ku (a heterodimer of Ku70 and Ku80 subunits) associates with mammalian telomeres and contributes to telomere maintenance. The Ku heterodimer functions at two kinds of DNA ends: telomeres and double-strand breaks. The role that Ku plays at these two classes of termini must be distinct, because Ku is required for accurate and efficient joining of double-strand breaks while similar DNA repair events are normally prohibited at chromosome ends.

Research Area

DATA IMAGES

Anti-Ku80 antibody used in Western Blot (WB). GTX70485

GTX70485 WB Image

The WB analysis of Ku80 antibody was published by Hacker KE and colleagues in the journal PLoS One in 2008.PMID: 19030229

Anti-Ku80 antibody used in Western Blot (WB). GTX70485

GTX70485 WB Image

The WB analysis of Ku80 antibody was published by Morales JC and colleagues in the journal PLoS Genet in 2016 . PMID: 27437695

REFERENCE

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 289