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Ku80 antibody

Anti-Ku80 antibody used in Western Blot (WB). GTX70485
Anti-Ku80 antibody used in Western Blot (WB). GTX70485
Anti-Ku80 antibody used in Western Blot (WB). GTX70485

Cat. No. GTX70485

Reference 6

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ELISA

Reactivity

 Human, Mouse
Package
100 μg ($399)
See all Ku80 products

APPLICATION

Application Note

Western blot - Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Product Note

Reacts with residues 323-338 [FSKVDEEQMKYKSEGK] of the 80 kDa Ku80 protein. Sequence is 100% conserved between human, mouse rat and hamster.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Purification

Affinity purified IgG

Conjugation

Unconjugated

RRID

AB_374164

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Background

Telomere length maintenance, an activity essential for chromosome stability and genome integrity, is regulated by telomerase- and telomere-associated factors. The DNA repair protein Ku (a heterodimer of Ku70 and Ku80 subunits) associates with mammalian telomeres and contributes to telomere maintenance. The Ku heterodimer functions at two kinds of DNA ends: telomeres and double-strand breaks. The role that Ku plays at these two classes of termini must be distinct, because Ku is required for accurate and efficient joining of double-strand breaks while similar DNA repair events are normally prohibited at chromosome ends.

Research Area

DATA IMAGES

Anti-Ku80 antibody used in Western Blot (WB). GTX70485

GTX70485 WB Image

The data was published in the journal PLoS One in 2014. PMID: 25180793

Anti-Ku80 antibody used in Western Blot (WB). GTX70485

GTX70485 WB Image

The data was published in the journal PLoS Genet in 2016. PMID: 27437695

Anti-Ku80 antibody used in Western Blot (WB). GTX70485

GTX70485 WB Image

The data was published in the journal PLoS One in 2008. PMID: 19030229

REFERENCE

Application Reference

Lipner MB et al. JCI Insight 2020; 5 (8) Irreversible JNK1-JUN inhibition by JNK-IN-8 sensitizes pancreatic cancer to 5-FU/FOLFOX chemotherapy.
Morales JC et al. PLoS Genet 2016; 12 (7) : e1006107 XRN2 Links Transcription Termination to DNA Damage and Replication Stress.
Application : WB
Reactivity : Human
Bailey ST et al. PLoS One 2014; 9 (9) : e104413 mTOR Inhibition Induces Compensatory, Therapeutically Targetable MEK Activation in Renal Cell Carcinoma.
Application : WB
Reactivity : Human
Wright TM et al. J Biol Chem 2010; 285 (17) : 12916-24 Identification of Ror2 as a hypoxia-inducible factor target in von Hippel-Lindau-associated renal cell carcinoma.
Myers K et al. PLoS Genet 2009; 5 (1) : e1000324 ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress.
Application : WB
Reactivity : Mouse
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399