GeneTex
United States (US)

Kv1.3 antibody

GTX16679_ICCIF_18121410_189.jpg
GTX16679_WB_1_18121410_879.jpg
GTX16679_FACS_18121410_740.jpg
GTX16679_WB_18121410_668.jpg

Cat No. GTX16679

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, FACS, IHC
Reactivity Human, Mouse, Rat
APPLICATION

Calculated MW

64 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Peptide KDYPASTSQDSFEA(C), corresponding to amino acid residues 263-276 of human Kv1.3. (accession number P22001). Extracellular loop between domains S1 and S2.

Purification

Affinity purified on immobilized antigen.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Potassium Voltage-Gated Channel Subfamily A Member 3,Hgk5,Hlk3,Hpcn3,Hukiii,Kv1.3,Mk3,Pcn3,Kcna3

Background

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1

Database

Research Area

DATA IMAGES
GTX16679_ICCIF_18121410_189.jpg

GTX16679 ICC/IF Image

Anti-KV1.3_(extracellular) - Expression of KV1.3 in HEK 293 transfected cells Immunocytochemical staining of live intact HEK 293 cells transfected with rat KV1.3 (panels A and C) or with empty vector (panels B and D) using Anti-KV1.3 (extracellular) antibody, (1:50). Staining (green) shows expression of KV1.3 in the transfected cells (A) but not in the cells transfected with empty vector (B). Panels C and D show the corresponding live image of the cells.

GTX16679_WB_1_18121410_879.jpg

GTX16679 WB Image

Anti-KV1.3_(extracellular) - Western blot analysis of human Jurkat T cells: 1. Anti-KV1.3 (extracellular) antibody, (1:200) 2. Anti-KV1.3 (extracellular) antibody, preincubated with the control peptide antigen.

GTX16679_FACS_18121410_740.jpg

GTX16679 FACS Image

Anti-KV1.3_(extracellular) - Indirect flow cytometry analysis of live intact human T cell leukemia (Jurkat) cell line: Black: Cells + goat-anti-rabbit-PE. Green: Cells + Anti-Kv1.3 (extracellular) antibody, (1:25) + goat-anti-rabbit-PE.

GTX16679_WB_18121410_668.jpg

GTX16679 WB Image

Anti-KV1.3_(extracellular) - Western blot analysis of rat brain membranes: 1. Anti-Kv1.3 (extracellular) antibody, (1:500). 2. Anti-Kv1.3 (extracellular) antibody, preincubated with the control peptide antigen.

Package List Price ($)
$ 329