Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
Assay dependent |
Assay dependent |
Assay dependent |
Assay dependent |
Not tested in other applications.
Calculated MW
Product Note
The antibody recognizes the HERG1b splice variant but not splice variants HERG1-3 and HERG-4.
Predict Reactivity
Rabbit, Dog(>80% identity)
Form
Liquid
Buffer
PBS, 1% BSA
Preservative
0.025% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.6 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
GST fusion protein with sequence DSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS, corresponding to amino acid residues 1106-1159 (Intracellular, C-terminus) of human Kv11.1 (HERG) (Accession : Q12809), (MW: 35 kDa.).
Purification
Depleted of anti-GST antibodies by affinity chromatography on immobilized GST and purified by antigen-affinity chromatography.
From serum
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Synonyms
potassium voltage-gated channel subfamily H member 2 , ERG-1 , ERG1 , H-ERG , HERG , HERG1 , Kv11.1 , LQT2 , SQT1
Cellular Localization
Cell membrane
Background
This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Database
Research Area