GeneTex
United States (US)

L1CAM antibody

KO/KD
GTX35239_20180822_WB_1_18121410_418.jpg
GTX35239_20180822_WB_18121410_594.jpg

Cat No. GTX35239

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
Not tested in other applications.

Calculated MW

140 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 50% glycerol, 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1143-1257 of human L1CAM (NP_000416.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

L1 Cell Adhesion Molecule,Caml1,Cd171,Hsas,Hsas1,Masa,Mic5,N-Cam-L1,N-Caml1,Ncam-L1,S10,Spg1,L1Cam

Background

The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]
DATA IMAGES
GTX35239_20180822_WB_1_18121410_418.jpg

GTX35239 WB Image

KO/KD

WB analysis of wild type and L1CAM knockout cell lysate using GTX35239 L1CAM antibody.
Dilution : 1:1000
Loading : 25μg per lane

GTX35239_20180822_WB_18121410_594.jpg

GTX35239 WB Image

KO/KD

WB analysis of various samples using GTX35239 L1CAM antibody.
Dilution : 1:1000
Loading : 25μg per lane

Package List Price ($)
$ 329