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L2HGDH antibody

Anti-L2HGDH antibody used in Western Blot (WB). GTX32695
Anti-L2HGDH antibody used in IHC (Paraffin sections) (IHC-P). GTX32695
Anti-L2HGDH antibody used in IHC (Paraffin sections) (IHC-P). GTX32695

Cat. No. GTX32695

Reference 3

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse
Package
100 μl ($419)
See all L2HGDH products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

50 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human L2HGDH (NP_079160.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_2887677

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

L-2-hydroxyglutarate dehydrogenase , C14orf160 , L2HGA

Cellular Localization

Mitochondrion

Background

This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe cognitive disability. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-L2HGDH antibody used in Western Blot (WB). GTX32695

GTX32695 WB Image

WB analysis of various sample lysates using GTX32695 L2HGDH antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-L2HGDH antibody used in IHC (Paraffin sections) (IHC-P). GTX32695

GTX32695 IHC-P Image

IHC-P analysis of human stomach tissue using GTX32695 L2HGDH antibody.
Dilution : 1:100

Anti-L2HGDH antibody used in IHC (Paraffin sections) (IHC-P). GTX32695

GTX32695 IHC-P Image

IHC-P analysis of mouse heart tissue using GTX32695 L2HGDH antibody.
Dilution : 1:100

REFERENCE

Application Reference

Kundu A et al. J Clin Invest 2024; 134 (13) l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models.
Brinkley G et al. Dis Model Mech 2020; 13 (11) Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney.
Shelar S et al. Clin Cancer Res 2018; (Epub) Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.
Application : WB
Reactivity : Human
Submit a Reference

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 419