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LAG3 antibody [17B4]

Cat No. GTX33931

Reference 9

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 17B4

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-Fr, IP, Functional Assay

Reactivity

 Human
Package
100 μg ($349)
See all LAG3 products

APPLICATION

Application Note

Functional Assay: Inhibition, Immunohistochemistry frozen sections: 1:150, Immunoprecipitation: 10μg/ml, Western Blot: 5μg/ml

Calculated MW

57 kDa. ( Note )

Specificity/Sensitivity

Recognizes human LAG-3.

PROPERTIES

Form

Liquid

Buffer

PBS containing 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide corresponding to 30 aa in the N-terminus of human LAG-3.

Purification

Protein A-affinity purified.

Purity

≧95% (SDS-PAGE)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Lymphocyte Activating 3 , Cd223 , Lag3

Background

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]

Database

REFERENCE

Clone Reference

Casati C et al. J Immunol 2008; 180 (6):687601 Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation.
Triebel F et al. Cancer Lett 2006; 235 (1):147-53 A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors.
Di Carlo E et al. J Pathol 2005; 205 (1):82-91 Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway.
Macon-Lemaitre L et al. Immunology 2005; 115 (2):170-8 The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells.
Demeure CE et al. Eur J Cancer 2001; 37 (13):1709-18 T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts.
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Clone Reference
Casati C et al. J Immunol 2008; 180 (6):687601 Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation.
Triebel F et al. Cancer Lett 2006; 235 (1):147-53 A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors.
Di Carlo E et al. J Pathol 2005; 205 (1):82-91 Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway.
Macon-Lemaitre L et al. Immunology 2005; 115 (2):170-8 The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells.
Demeure CE et al. Eur J Cancer 2001; 37 (13):1709-18 T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts.
Hannier S et al. J Immunol 1998; 161 (8):4058-65 CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling.
Huard B et al. Proc Natl Acad Sci U S A 1997; 94 (11):1404238 Characterization of the major histocompatibility complex class II binding site on LAG-3 protein.
Huard B et al. Immunogenetics 1994; 39 (3):213-7 Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand.
Baixeras E et al. J Exp Med 1992; 176 (2):327-37 Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.
Package List Price ($)
$ 349