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LAG3 antibody [17B4]

Cat. No. GTX33931

Reference 9

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 17B4

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-Fr, IP, Neutralizing/Inhibition

Reactivity

 Human
Package
100 μg ($439)
See all LAG3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-Fr Assay dependent
IP Assay dependent
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

57 kDa. ( Note )

Product Note

Recognizes human LAG-3.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide corresponding to 30 aa in the N-terminus of human LAG-3.

Purification

Protein A-affinity purified.

Purity

??95% by SDS-PAGE.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

lymphocyte activating 3 , CD223

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Clone Reference

Casati C et al. J Immunol 2008; 180 (6):687601 Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation.
Triebel F et al. Cancer Lett 2006; 235 (1):147-53 A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors.
Di Carlo E et al. J Pathol 2005; 205 (1):82-91 Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway.
Macon-Lemaitre L et al. Immunology 2005; 115 (2):170-8 The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells.
Demeure CE et al. Eur J Cancer 2001; 37 (13):1709-18 T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts.
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Clone Reference
Casati C et al. J Immunol 2008; 180 (6):687601 Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation.
Triebel F et al. Cancer Lett 2006; 235 (1):147-53 A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors.
Di Carlo E et al. J Pathol 2005; 205 (1):82-91 Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway.
Macon-Lemaitre L et al. Immunology 2005; 115 (2):170-8 The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells.
Demeure CE et al. Eur J Cancer 2001; 37 (13):1709-18 T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts.
Hannier S et al. J Immunol 1998; 161 (8):4058-65 CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling.
Huard B et al. Proc Natl Acad Sci U S A 1997; 94 (11):1404238 Characterization of the major histocompatibility complex class II binding site on LAG-3 protein.
Huard B et al. Immunogenetics 1994; 39 (3):213-7 Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand.
Baixeras E et al. J Exp Med 1992; 176 (2):327-37 Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 439