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LAG3 antibody [C9B7W] (PE)

Anti-LAG3 antibody [C9B7W] (PE) used in Flow cytometry (FACS). GTX43144

Cat. No. GTX43144

Reference 2

Host

 Rat

Clonality

 Monoclonal

Clone Name

 C9B7W

Isotype

 IgG1

Application

 FACS

Reactivity

 Mouse
Package
100 μg ($439)
See all LAG3 products
PRODUCT

Summary

The C9B7W monoclonal antibody reacts with mouse CD223, also known as Lymphocyte-activation gene 3 (LAG3). CD223 is a 70 kDa member of the Ig superfamily and is structurally homologous to CD4. Like CD4, CD223 binds to MHC Class II but with higher affinity than CD4. CD223 is expressed on T cells activated through the T cell receptor and on activated NK cells.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
Not tested in other applications.

Calculated MW

57 kDa. ( Note )

Product Note

This antibody recognizes an epitope within the D2 domain of LAG3.

PROPERTIES

Form

Liquid

Buffer

10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Murine LAG3 Ig fusion protein.

Purification

Purified by affinity chromatography
From tissue culture supernatant

Conjugation

Phycoerythrin (PE) Wavelength

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

lymphocyte-activation gene 3 , CD223 , LAG-3 , Ly66

Cellular Localization

Membrane; Single-pass type I membrane protein

Database

Research Area

DATA IMAGES

Anti-LAG3 antibody [C9B7W] (PE) used in Flow cytometry (FACS). GTX43144

GTX43144 FACS Image

FACS analysis of C57Bl/6 splenocytes stimulated for 3 days with ConA stained APC anti-mouse CD3 antibody, followed by staining with GTX43144 LAG3 antibody [C9B7W] (PE).
Right panel : Co-stained with APC anti-mouse CD3 antibody and GTX43144
Left panel : Co-stained with APC anti-mouse CD3 antibody and PE rat IgG1 isotype control
Antibody amount : 0.5 μg

REFERENCE

Clone Reference

Scarlett UK et al. J Exp Med 2012; 209 (3):495-506 Ovarian cancer progression is controlled by phenotypic changes in dendritic cells.
Meng Q et al. Invest Ophthalmol Vis Sci 2006; 47 (10):4444-52 CD4+PD-1+ T cells acting as regulatory cells during the induction of anterior chamber-associated immune deviation.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 439