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LAMP2 antibody [GL2A7]

Anti-LAMP2 antibody [GL2A7] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX13524
Anti-LAMP2 antibody [GL2A7] used in Western Blot (WB). GTX13524

Cat. No. GTX13524

Reference 7

Host

 Rat

Clonality

 Monoclonal

Clone Name

 GL2A7

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, FACS, IP

Reactivity

 Human, Mouse, Rabbit
Package
100 μl ($399)
See all LAMP2 products

APPLICATION

Application Note

ICC: Use at a dilution of 1/100. The antibody will label the presumptive lysosomes and late endosomes in cells that have been permeabilized with saponin. IP: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

45 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Ascites

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Mouse

Immunogen

Purified preparation of mouse liver lysosomal membranes.

Purification

Unpurified

Conjugation

Unconjugated

RRID

AB_369111

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

lysosomal associated membrane protein 2 , CD107b , LAMP-2 , LAMPB , LGP-96 , LGP110

Cellular Localization

Cell membrane , Endosome membrane , Lysosome membrane

Background

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-LAMP2 antibody [GL2A7] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX13524

GTX13524 ICC/IF Image

Mouse astrocytes stained with VAM-EN003. Cells were fixed using 4% paraformaldehyde and permeabilized using 0.01% saponin

Anti-LAMP2 antibody [GL2A7] used in Western Blot (WB). GTX13524

GTX13524 WB Image

The data was published in the journal EMBO Mol Med in 2019.PMID: 30552094

REFERENCE

Application Reference

Bonsi P et al. EMBO Mol Med 2019; 11 (1) RGS9-2 Rescues Dopamine D2 Receptor Levels and Signaling in DYT1 Dystonia Mouse Models.
Lin KC et al. Theranostics 2018; 8 (9) : 2477-2487 Graphene oxide sensitizes cancer cells to chemotherapeutics by inducing early autophagy events, promoting nuclear trafficking and necrosis.
Lin K.C. et al. Theranostics 2018; 8 (9) : 2477-2487 Graphene oxide sensitizes cancer cells to chemotherapeutics by inducing early autophagy events, promoting nuclear trafficking and necrosis.
Application : ICC/IF
Reactivity : Human

Clone Reference

Nag S et al. J Cell Sci. 2018; 131 (18) Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles
Application : WB, ICC/IF
Reactivity : Mouse
Dallari S et al. Nat Commun. 2017; Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses.
Application : FACS
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Package List Price ($)
$ 399