APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 - 2 μg/mL |
| 2.5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Human Liver Tissue Slide , Human Liver Tissue Lysate
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
LDL-R antibody was raised against an 18 amino acid synthetic peptide near the center of human LDL-R.The immunogen is located within amino acids 490 - 540 of LDL-R.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
low density lipoprotein receptor , FH , FHC , LDLCQ2
Cellular Localization
Cell membrane,Golgi apparatus,Lysosome
Background
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
Database
Research Area
DATA IMAGES
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GTX85109 IHC-P Image
IHC-P analysis of human liver tissue using GTX85109 LDL Receptor antibody.
Working concentration : 20 μg/ml
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GTX85109 IHC-P Image
IHC-P analysis of human liver tissue using GTX85109 LDL Receptor antibody.
Working concentration : 2.5 μg/ml
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GTX85109 WB Image
WB analysis of human liver tissue lysate using GTX85109 LDL Receptor antibody.
Working concentration : (A) 1 and (B) 2 μg/ml
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REFERENCE
There are currently no references for LDL Receptor antibody (GTX85109). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for LDL Receptor antibody (GTX85109). Be the first to share your experience with this product.
