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LEF1 antibody [1C3.1D10]

Cat. No. GTX12033

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 1C3.1D10

Isotype

 IgG1

Application

 WB

Reactivity

 Human
Package
50 μg ($399)
See all LEF1 products

APPLICATION

Application Note

WB: Use at a concentration of 1 - 5 μg/ml. Predicted MW 55-57 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

44 kDa. ( Note )

Product Note

Recognizes all human LEF1 isoforms using Western blotting. The antibody does not cross-react with TCF1 or TCF4.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.08% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: TGIPHPAIVT PQVKQEHPHT DSDLMHVKPQ HEQRKEQEPK RP, corresponding to amino acids 256-297 of Human LEF1.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

lymphoid enhancer binding factor 1 , LEF-1 , TCF10 , TCF1ALPHA , TCF7L3

Cellular Localization

Nucleus

Background

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399