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LEF1 antibody [REMB1]

Cat. No. GTX12034

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 REMB1

Isotype

 IgG1

Application

 WB, ICC/IF

Reactivity

 Human, Mouse
Package
50 μg ($399)
See all LEF1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1-5 μg/ml
ICC/IF Assay dependent
Not tested in other applications.

Calculated MW

44 kDa. ( Note )

Positive Control

Jurkat

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.08% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

~1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

full length recombinant LEF-1.

Purification

Purified immunoglobulin

Conjugation

Unconjugated

RRID

AB_372167

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

lymphoid enhancer binding factor 1 , LEF-1 , TCF10 , TCF1ALPHA , TCF7L3

Cellular Localization

Nucleus

Background

Lymphoid enhancer factor, LEF1, is a transcription factor of the High Mobility Group of DNA binding proteins. It is one member of a family of four proteins referred to as LEF/TCF transcription factors (LEF1, TCF1, TCF3 and TCF4). These factors play crucial roles in WNT/Wingless signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer, melanoma and breast cancer.

Database

Research Area

REFERENCE

Application Reference

Lancaster MA et al. Nat Med 2009; 15 (9) : 1046-54 Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy.
Application : ICC/IF
Reactivity : Mouse
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399