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LGI2 antibody

Anti-LGI2 antibody used in Western Blot (WB). GTX85408
Anti-LGI2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85408
Anti-LGI2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85408

Cat. No. GTX85408

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse
Package
100 μg ($399)
See all LGI2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

63 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , Mouse Liver Tissue Lysate(GTX27935)

Product Note

This LGI2 antibody is predicted to be specific to LGI2 and not recognize other LGI proteins.Three isoforms of LGI2 are known to exist; this LGI2 antibody will recognize only the longest.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

LGI2 antibody was raised against a 10 amino acid synthetic peptide from near the center of human LGI2.The immunogen is located within amino acids 290 - 340 of LGI2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

leucine-rich repeat LGI family, member 2 , mKIAA1916

Cellular Localization

Secreted

Background

The leucine-rich, glioma inactivated gene 2 (LGI2) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI2 have not been found to be associated with ADTLE. Three isoforms of LGI2 are known to exist; this LGI2 antibody will recognize only the longest. This LGI2 antibody is predicted to be specific to LGI2 and not recognize other LGI proteins.

Database

DATA IMAGES

Anti-LGI2 antibody used in Western Blot (WB). GTX85408

GTX85408 WB Image

WB analysis of mouse liver tissue lysate using GTX85408 LGI2 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

Anti-LGI2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85408

GTX85408 IHC-P Image

IHC-P analysis of human brain tissue using GTX85408 LGI2 antibody.
Working concentration : 5 μg/ml

Anti-LGI2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85408

GTX85408 IHC-P Image

IHC-P analysis of human brain tissue using GTX85408 LGI2 antibody.
Working concentration : 2.5 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399